Abstract
Background: Older adults with type 2 diabetes mellitus (T2DM) are at an increased risk of cognitive decline and dementia. Left ventricular hypertrophy (LVH) is prevalent in T2DM and is independently associated with cognitive decline. We conducted a study to establish whether T2DM patients with LVH have increased rates of brain atrophy and cognitive impairment.
Methods: Thirty-seven cognitively healthy adults (50 years and older) with T2DM were divided into those with (n=13) and without (n=24) LVH. All participants completed neuropsychological assessments, health-and-lifestyle questionnaires, 24-hour ambulatory blood pressure monitoring, an echocardiogram and a 3T-MRI scan. FreeSurfer (version 6.0) was used to estimate total brain volume (TBV), mean cortical thickness and subcortical volumes, including the thalami and caudate nuclei. TBV was expressed as a percentage of intracranial volume. Averages between left and right volumes were calculated for subcortical structures. Left ventricular mass was indexed to height2.7 using the American Society of Echocardiography criteria. LVH was defined as >49g/m2.7 for males and >45g/m2.7 for females. Three cognitive domains (visuospatial skills, verbal memory and executive functions) were derived through factor analysis. These variables were used to compare cognitive performance between individuals with and without LVH.
Results: There was a higher percentage of women (x2=11.01, df=1, pConclusions: The presence of LVH in individuals with T2DM was associated with atrophy in the cerebellar cortex and in the amygdala, as well as with poorer visuospatial function.
Methods: Thirty-seven cognitively healthy adults (50 years and older) with T2DM were divided into those with (n=13) and without (n=24) LVH. All participants completed neuropsychological assessments, health-and-lifestyle questionnaires, 24-hour ambulatory blood pressure monitoring, an echocardiogram and a 3T-MRI scan. FreeSurfer (version 6.0) was used to estimate total brain volume (TBV), mean cortical thickness and subcortical volumes, including the thalami and caudate nuclei. TBV was expressed as a percentage of intracranial volume. Averages between left and right volumes were calculated for subcortical structures. Left ventricular mass was indexed to height2.7 using the American Society of Echocardiography criteria. LVH was defined as >49g/m2.7 for males and >45g/m2.7 for females. Three cognitive domains (visuospatial skills, verbal memory and executive functions) were derived through factor analysis. These variables were used to compare cognitive performance between individuals with and without LVH.
Results: There was a higher percentage of women (x2=11.01, df=1, pConclusions: The presence of LVH in individuals with T2DM was associated with atrophy in the cerebellar cortex and in the amygdala, as well as with poorer visuospatial function.
| Original language | English |
|---|---|
| Number of pages | 1 |
| Publication status | Published - 7 Dec 2020 |
| Event | Alzheimer's Association International Conference 2020 - Virtual Duration: 27 Jul 2020 → 31 Jul 2020 https://alz-journals.onlinelibrary.wiley.com/toc/15525279/2020/16/S6 https://alz.confex.com/alz/20amsterdam/meetingapp.cgi/Home/0 |
Conference
| Conference | Alzheimer's Association International Conference 2020 |
|---|---|
| Abbreviated title | AAIC 2020 |
| Period | 27/07/20 → 31/07/20 |
| Internet address |
