@article{92c37736132948528411ac09137e4ddd,
title = "Coffee consumption revealed sex differences in host endogenous metabolism and gut microbiota in healthy adults",
abstract = "Coffee is rich in antioxidant and has been shown to confer various health benefits. Here, we investigated the effect of single-dose coffee consumption in healthy human subjects. About 30 healthy volunteers were recruited and given a serving of sugar free black coffee. Urine and fecal samples were collected and analyzed. Significant changes in urinary metabolites relating to coffee, gut microbial and host energy metabolisms were observed post-coffee consumption. Clear sex differences were also observed in the urinary metabolic profiles pre- and post-coffee consumption. Sex differences in richness and composition of gut microbiota were observed, however, the effect of single-dose coffee consumption on host gut microbiota were unremarkable. These findings indicated that single-dose coffee consumption affects sex-specific host metabolic responses that relates to gut-microbe and energy metabolism. This study demonstrated the utility of systems biology tools to unravel complexity of host-diet biology and gut microbial responses. Practical applications: This study demonstrated that integrated systems biology approach enabled efficient extractions of host biochemical and microbial information that allows food industry to ascertain the impact of diet and longitudinal assessment of potential functional food in humans.",
keywords = "coffee, gut microbiota, metabonomics, nutritional systems biology",
author = "Chong, {Chun Wie} and Wong, {Lai Chun} and Teh, {Cindy S.J.} and Ismail, {Nor Hadiani} and Chan, {Pei Qi} and Lim, {Chiu Sien} and Yap, {Siu Ching} and Yap, {Ivan K.S.}",
note = "Funding Information: This research is supported by the International Medical University Bachelor of Pharmacy Student Research Fund (BP I‐01/12 (09) 2015). NMR signal processing and multivariate in‐house software were developed by Dr O. Cloarec, Dr T. Ebbels, Dr Kirill A. Veselkov, Dr H. Keun, and Dr M. Rantalainen (Biomolecular Medicine, Department of Surgery and Cancer, Imperial College London). The authors also acknowledge the NMR facilities provided by Atta‐ur‐Rahman Institute for Natural Products Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Selangor, Malaysia, and Mr MT Kho for student training. Funding Information: This research is supported by the International Medical University Bachelor of Pharmacy Student Research Fund (BP I-01/12 (09) 2015). NMR signal processing and multivariate in-house software were developed by Dr O. Cloarec, Dr T. Ebbels, Dr Kirill A. Veselkov, Dr H. Keun, and Dr M. Rantalainen (Biomolecular Medicine, Department of Surgery and Cancer, Imperial College London). The authors also acknowledge the NMR facilities provided by Atta-ur-Rahman Institute for Natural Products Discovery, Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Selangor, Malaysia, and Mr MT Kho for student training. Publisher Copyright: {\textcopyright} 2020 Wiley Periodicals LLC. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = dec,
doi = "10.1111/jfbc.13535",
language = "English",
volume = "44",
journal = "Journal of Food Biochemistry",
issn = "1745-4514",
publisher = "Wiley-Blackwell",
number = "12",
}