Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

Tamas L Horvath; Sabrina Diano; Csaba Leranth; Luis Miguel Garcia-Segura; Michael Alexander Cowley; Marya Shananbrough; John D Elsworth; Peter Sotonyi; Robert H Roth; Edwin H Dietrich; Russel T Matthews; Colin J Barnstable; D Eugene Redmond Jr.

doi:10.1210/en.2003-0163

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

Tamas L Horvath, Sabrina Diano, Csaba Leranth, Luis Miguel Garcia-Segura, Michael Alexander Cowley, Marya Shananbrough, John D Elsworth, Peter Sotonyi, Robert H Roth, Edwin H Dietrich, Russel T Matthews, Colin J Barnstable, D Eugene Redmond Jr.

Physiology

Research output: Contribution to journal › Article › Research › peer-review

108 Citations (Scopus)

Abstract

Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.

Original language	English
Pages (from-to)	2757-2760
Number of pages	4
Journal	Endocrinology
Volume	144
Issue number	7
DOIs	https://doi.org/10.1210/en.2003-0163
Publication status	Published - 1 Jul 2003

Access to Document

10.1210/en.2003-0163

Cite this

Horvath, T. L., Diano, S., Leranth, C., Garcia-Segura, L. M., Cowley, M. A., Shananbrough, M., Elsworth, J. D., Sotonyi, P., Roth, R. H., Dietrich, E. H., Matthews, R. T., Barnstable, C. J., & Redmond Jr., D. E. (2003). Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology, 144(7), 2757-2760. https://doi.org/10.1210/en.2003-0163

@article{c74906803c164022adc9634d0f8e23bf,

title = "Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease",

abstract = "Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.",

author = "Horvath, \{Tamas L\} and Sabrina Diano and Csaba Leranth and Garcia-Segura, \{Luis Miguel\} and Cowley, \{Michael Alexander\} and Marya Shananbrough and Elsworth, \{John D\} and Peter Sotonyi and Roth, \{Robert H\} and Dietrich, \{Edwin H\} and Matthews, \{Russel T\} and Barnstable, \{Colin J\} and \{Redmond Jr.\}, \{D Eugene\}",

year = "2003",

month = jul,

day = "1",

doi = "10.1210/en.2003-0163",

language = "English",

volume = "144",

pages = "2757--2760",

journal = "Endocrinology",

issn = "0013-7227",

publisher = "Oxford University Press, USA",

number = "7",

}

Horvath, TL, Diano, S, Leranth, C, Garcia-Segura, LM, Cowley, MA, Shananbrough, M, Elsworth, JD, Sotonyi, P, Roth, RH, Dietrich, EH, Matthews, RT, Barnstable, CJ & Redmond Jr., DE 2003, 'Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease', Endocrinology, vol. 144, no. 7, pp. 2757-2760. https://doi.org/10.1210/en.2003-0163

TY - JOUR

T1 - Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

AU - Horvath, Tamas L

AU - Diano, Sabrina

AU - Leranth, Csaba

AU - Garcia-Segura, Luis Miguel

AU - Cowley, Michael Alexander

AU - Shananbrough, Marya

AU - Elsworth, John D

AU - Sotonyi, Peter

AU - Roth, Robert H

AU - Dietrich, Edwin H

AU - Matthews, Russel T

AU - Barnstable, Colin J

AU - Redmond Jr., D Eugene

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.

AB - Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.

UR - https://www.scopus.com/pages/publications/0038336912

U2 - 10.1210/en.2003-0163

DO - 10.1210/en.2003-0163

M3 - Article

C2 - 12810526

SN - 0013-7227

VL - 144

SP - 2757

EP - 2760

JO - Endocrinology

JF - Endocrinology

IS - 7

ER -

Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

Abstract

Access to Document

Other files and links

Cite this