Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease

Tamas L Horvath, Sabrina Diano, Csaba Leranth, Luis Miguel Garcia-Segura, Michael Alexander Cowley, Marya Shananbrough, John D Elsworth, Peter Sotonyi, Robert H Roth, Edwin H Dietrich, Russel T Matthews, Colin J Barnstable, D Eugene Redmond Jr.

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Abstract

Parkinson's disease is characterized by dopamine cell loss of the substantia nigra. Parkinson's disease and the neurotoxin 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine may destroy dopamine neurons through oxidative stress. Coenzyme Q is a cofactor of mitochondrial uncoupling proteins that enhances state-4 respiration and eliminate superoxides. Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys.

Original languageEnglish
Pages (from-to)2757-2760
Number of pages4
JournalEndocrinology
Volume144
Issue number7
DOIs
Publication statusPublished - 1 Jul 2003

Cite this

Horvath, T. L., Diano, S., Leranth, C., Garcia-Segura, L. M., Cowley, M. A., Shananbrough, M., Elsworth, J. D., Sotonyi, P., Roth, R. H., Dietrich, E. H., Matthews, R. T., Barnstable, C. J., & Redmond Jr., D. E. (2003). Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease. Endocrinology, 144(7), 2757-2760. https://doi.org/10.1210/en.2003-0163