A gene cluster for the non-ribosomal synthesis of a peptide of unknown structure has been identified in the partial genome sequence of Streptomyces coelicolor. Using molecular and computational analyses, the total structure of a tripeptide siderophore synthesized by the non-ribosomal peptide synthetase within the cluster has been deduced from the translated sequence of its encoding gene. This represents a novel method for the structural assignment of natural products from genome sequence data. (C) 2000 Published by Elsevier Science B.V.
|Number of pages||4|
|Journal||FEMS Microbiology Letters|
|Publication status||Published - 15 Jun 2000|
- Non-ribosomal peptide synthetase