Coelichelin, a new peptide siderophore encoded by the Streptomyces coelicolor genome: Structure prediction from the sequence of its non- ribosomal peptide synthetase

Gregory L. Challis, Jacques Ravel

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144 Citations (Scopus)

Abstract

A gene cluster for the non-ribosomal synthesis of a peptide of unknown structure has been identified in the partial genome sequence of Streptomyces coelicolor. Using molecular and computational analyses, the total structure of a tripeptide siderophore synthesized by the non-ribosomal peptide synthetase within the cluster has been deduced from the translated sequence of its encoding gene. This represents a novel method for the structural assignment of natural products from genome sequence data. (C) 2000 Published by Elsevier Science B.V.

Original languageEnglish
Pages (from-to)111-114
Number of pages4
JournalFEMS Microbiology Letters
Volume187
Issue number2
DOIs
Publication statusPublished - 15 Jun 2000
Externally publishedYes

Keywords

  • Genomic
  • Non-ribosomal peptide synthetase
  • Siderophore
  • Streptomyces

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