Codelivery of doxorubicin and sodium tanshinone IIA sulfonate using multicompartmentalized vesosomes to enhance synergism and prevent doxorubicin-induced cardiomyocyte apoptosis

Xunan Zhang, Wei Zong, Wenlong Cheng, Xiaojun Han

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6 Citations (Scopus)

Abstract

Doxorubicin, one of the most effective antitumor drugs, causes serious adverse cardiac effects. As a derivative of tanshinone IIA, sodium tanshinone IIA sulfonate was exploited for curing cardiovascular disorders. The synergistic effect of the above drugs as a combination was investigated for treating cancer cells and attenuating myocardial apoptosis. A multicompartmentalized vesosome (MCV) was produced to co-deliver the drug combination. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and western blotting analysis demonstrated that the MCV can enhance the synergistic effect of the drug combination and promote the protection of STS in Dox-induced cardiomyocyte apoptosis.

Original languageEnglish
Pages (from-to)5243-5247
Number of pages5
JournalJournal of Materials Chemistry B
Volume6
Issue number32
DOIs
Publication statusPublished - 2018

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