Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells

Rui Li, Sivapriya Pavuluri, Kiara Bruggeman, Benjamin M. Long, Andrew J. Parnell, Anne Martel, Steven R. Parnell, Frederick M Pfeffer, Andrew J.C. Dennison, Kevin R. Nicholas, Colin J Barrow, David R. Nisbet, Richard J Williams

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti-inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomaterial for cancer therapy. We show that it supports healthy cells, while inducing apoptosis in cancerous epithelial cells, as demonstrated by the significant down-regulation of gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications in local epithelial cancer immunotherapy and drug delivery.

Original languageEnglish
Pages (from-to)1397-1407
Number of pages11
JournalNanomedicine-Nanotechnology Biology and Medicine
Volume12
Issue number5
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

Keywords

  • Bionanotechnology
  • Cancer
  • Hydrogels
  • Self-assembly
  • Supramolecular materials
  • Tissue engineering

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