Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa

Mohammad Al-Tamimi, George Grigoriadis, Huy Tran, Eldho Paul, Patricia Servadei, Michael Berndt, Elizabeth Ellen Gardiner, Robert Keith Andrews

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Abstract

This study evaluated shedding of the platelet collagen receptor, glycoprotein VI (GPVI) in human plasma. Collagen or other ligands induce metalloproteinase-mediated GPVI ectodomain shedding, generating approximately 55-kDa soluble GPVI (sGPVI) and approximately 10-kDa platelet-associated fragments. In the absence of GPVI ligands, coagulation of platelet-rich plasma from healthy persons induced GPVI shedding, independent of added tissue factor, but inhibitable by metalloproteinase inhibitor, GM6001.
Original languageEnglish
Pages (from-to)3912 - 3920
Number of pages9
JournalBlood
Volume117
Issue number14
DOIs
Publication statusPublished - 2011

Cite this