Co-sprayed dried antibiotics for dry powder inhalation delivery

Daniela Traini, Paul Michael Young, Hak-Kim Chan, Peter James Stewart, Handoko Adi

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

Inhaled antiobiotics can potentially be delivered in high concentrations to the site of infection in the airways, with low systemic bioavailability, thus reducing toxicity. Currently antibiotic inhalation therapy is limited to nebulizers (1) which are cumbersome, expensive and require routine maintenance (2). Furthermore, these nebulizer delivery systems have, in general, low efficiency and poor reproductibility of delivery. Dry powder antibiotic inhalation may provide a suitable alternative to drug nebulization for high dose delivery. To the authors knowledge, no combination dry powder antibiotic inhalation product exists, and few studies exist, and few studies report inhalation of micronized antibiotics (3-6). The aim of this study was to assess the in vitro aerosolization suitability of a combination antibiotic product comprimising of doxycycline and ciprofloxacin, as a dry powder (DPI) formulation.
Original languageEnglish
Title of host publicationRDD Europe 2007
EditorsRichard N Dalby, Peter R Byron, Joanne Peart, Juli D Suman
Place of PublicationUnited States of America
PublisherVirginia Commonwealth University
Pages369 - 372
Number of pages4
ISBN (Print)193372207X
Publication statusPublished - 2007
EventRespiratory Drug Delivery 2007 - Paris France, United States of America
Duration: 1 Jan 2007 → …

Conference

ConferenceRespiratory Drug Delivery 2007
CityUnited States of America
Period1/01/07 → …

Cite this

Traini, D., Young, P. M., Chan, H-K., Stewart, P. J., & Adi, H. (2007). Co-sprayed dried antibiotics for dry powder inhalation delivery. In R. N. Dalby, P. R. Byron, J. Peart, & J. D. Suman (Eds.), RDD Europe 2007 (pp. 369 - 372). Virginia Commonwealth University.