CMOS stimulating chips capable of wirelessly driving 473 electrodes for a cortical vision prosthesis

Yan T. Wong, Tim Feleppa, Anand Mohan, Damien Browne, Julian Szlawski, Jeffrey V. Rosenfeld, Arthur Lowery

Research output: Contribution to journalArticleResearchpeer-review

Abstract

OBJECTIVE: Implantable neural stimulating and recording devices have the potential to restore capabilities such as vision or motor control to disabled patients, improving quality of life. Implants with a large number of stimulating electrodes typically utilize implanted batteries and/or subcutaneous wiring to deal with their high-power consumption and high data throughput needed to address all electrodes with low latency. The use of batteries places severe limitations on the implant's size, usable duty cycle, device longevity while subcutaneous wiring increases the risk of infection and mechanical damage due to device movement. APPROACH: To overcome these limitations, we have designed and implemented a system that supports up to 473 implanted stimulating microelectrodes, all wirelessly powered and individually controlled by micropower application specific integrated circuits (ASICs). MAIN RESULTS: Each ASIC controls 43 electrodes and draws 3.18 mW of power when stimulating through 24 channels. We measured the linearity of the digital-to-analog convertors (DACs) to be 0.21 LSB (integrated non-linearity) and the variability in timing of stimulation pulses across ASICs to be 172 ns. SIGNIFICANCE: This work demonstrates the feasibility of a new low power ASIC designed to be implanted in the visual cortex of humans. The fully implantable device will greatly reduce the risks of infection and damage due to mechanical issues.

Original languageEnglish
Article number026025
Number of pages14
JournalJournal of Neural Engineering
Volume16
Issue number2
DOIs
Publication statusPublished - 1 Apr 2019

Cite this

Wong, Yan T. ; Feleppa, Tim ; Mohan, Anand ; Browne, Damien ; Szlawski, Julian ; Rosenfeld, Jeffrey V. ; Lowery, Arthur. / CMOS stimulating chips capable of wirelessly driving 473 electrodes for a cortical vision prosthesis. In: Journal of Neural Engineering. 2019 ; Vol. 16, No. 2.
@article{692381c5e0b540d2a1296d100fa966dd,
title = "CMOS stimulating chips capable of wirelessly driving 473 electrodes for a cortical vision prosthesis",
abstract = "OBJECTIVE: Implantable neural stimulating and recording devices have the potential to restore capabilities such as vision or motor control to disabled patients, improving quality of life. Implants with a large number of stimulating electrodes typically utilize implanted batteries and/or subcutaneous wiring to deal with their high-power consumption and high data throughput needed to address all electrodes with low latency. The use of batteries places severe limitations on the implant's size, usable duty cycle, device longevity while subcutaneous wiring increases the risk of infection and mechanical damage due to device movement. APPROACH: To overcome these limitations, we have designed and implemented a system that supports up to 473 implanted stimulating microelectrodes, all wirelessly powered and individually controlled by micropower application specific integrated circuits (ASICs). MAIN RESULTS: Each ASIC controls 43 electrodes and draws 3.18 mW of power when stimulating through 24 channels. We measured the linearity of the digital-to-analog convertors (DACs) to be 0.21 LSB (integrated non-linearity) and the variability in timing of stimulation pulses across ASICs to be 172 ns. SIGNIFICANCE: This work demonstrates the feasibility of a new low power ASIC designed to be implanted in the visual cortex of humans. The fully implantable device will greatly reduce the risks of infection and damage due to mechanical issues.",
author = "Wong, {Yan T.} and Tim Feleppa and Anand Mohan and Damien Browne and Julian Szlawski and Rosenfeld, {Jeffrey V.} and Arthur Lowery",
year = "2019",
month = "4",
day = "1",
doi = "10.1088/1741-2552/ab021b",
language = "English",
volume = "16",
journal = "Journal of Neural Engineering",
issn = "1741-2560",
publisher = "IOP Publishing",
number = "2",

}

CMOS stimulating chips capable of wirelessly driving 473 electrodes for a cortical vision prosthesis. / Wong, Yan T.; Feleppa, Tim; Mohan, Anand; Browne, Damien; Szlawski, Julian; Rosenfeld, Jeffrey V.; Lowery, Arthur.

In: Journal of Neural Engineering, Vol. 16, No. 2, 026025, 01.04.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - CMOS stimulating chips capable of wirelessly driving 473 electrodes for a cortical vision prosthesis

AU - Wong, Yan T.

AU - Feleppa, Tim

AU - Mohan, Anand

AU - Browne, Damien

AU - Szlawski, Julian

AU - Rosenfeld, Jeffrey V.

AU - Lowery, Arthur

PY - 2019/4/1

Y1 - 2019/4/1

N2 - OBJECTIVE: Implantable neural stimulating and recording devices have the potential to restore capabilities such as vision or motor control to disabled patients, improving quality of life. Implants with a large number of stimulating electrodes typically utilize implanted batteries and/or subcutaneous wiring to deal with their high-power consumption and high data throughput needed to address all electrodes with low latency. The use of batteries places severe limitations on the implant's size, usable duty cycle, device longevity while subcutaneous wiring increases the risk of infection and mechanical damage due to device movement. APPROACH: To overcome these limitations, we have designed and implemented a system that supports up to 473 implanted stimulating microelectrodes, all wirelessly powered and individually controlled by micropower application specific integrated circuits (ASICs). MAIN RESULTS: Each ASIC controls 43 electrodes and draws 3.18 mW of power when stimulating through 24 channels. We measured the linearity of the digital-to-analog convertors (DACs) to be 0.21 LSB (integrated non-linearity) and the variability in timing of stimulation pulses across ASICs to be 172 ns. SIGNIFICANCE: This work demonstrates the feasibility of a new low power ASIC designed to be implanted in the visual cortex of humans. The fully implantable device will greatly reduce the risks of infection and damage due to mechanical issues.

AB - OBJECTIVE: Implantable neural stimulating and recording devices have the potential to restore capabilities such as vision or motor control to disabled patients, improving quality of life. Implants with a large number of stimulating electrodes typically utilize implanted batteries and/or subcutaneous wiring to deal with their high-power consumption and high data throughput needed to address all electrodes with low latency. The use of batteries places severe limitations on the implant's size, usable duty cycle, device longevity while subcutaneous wiring increases the risk of infection and mechanical damage due to device movement. APPROACH: To overcome these limitations, we have designed and implemented a system that supports up to 473 implanted stimulating microelectrodes, all wirelessly powered and individually controlled by micropower application specific integrated circuits (ASICs). MAIN RESULTS: Each ASIC controls 43 electrodes and draws 3.18 mW of power when stimulating through 24 channels. We measured the linearity of the digital-to-analog convertors (DACs) to be 0.21 LSB (integrated non-linearity) and the variability in timing of stimulation pulses across ASICs to be 172 ns. SIGNIFICANCE: This work demonstrates the feasibility of a new low power ASIC designed to be implanted in the visual cortex of humans. The fully implantable device will greatly reduce the risks of infection and damage due to mechanical issues.

UR - http://www.scopus.com/inward/record.url?scp=85062882202&partnerID=8YFLogxK

U2 - 10.1088/1741-2552/ab021b

DO - 10.1088/1741-2552/ab021b

M3 - Article

VL - 16

JO - Journal of Neural Engineering

JF - Journal of Neural Engineering

SN - 1741-2560

IS - 2

M1 - 026025

ER -