TY - JOUR
T1 - Clozapine and olanzapine treatment decreases rat cortical and limbic GABA(A) receptors
AU - Farnbach-Pralong, Danièle
AU - Bradbury, Robyn
AU - Copolov, David
AU - Dean, Brian
PY - 1998/5/22
Y1 - 1998/5/22
N2 - The density of GABA(A) receptors in the hippocampus and the temporal cortex from rats treated for 28 days with either haloperidol, chlorpromazine, clozapine or olanzapine was measured. Compared to haloperidol (0.01 and 0.1 mg kg-1 day-1) and chlorpromazine (0.1 and 1 mg kg-1 day-1), clozapine and olanzapine (0.1 and 1 mg kg-1 day-1) markedly decreased the density of GABA(A) receptors in these two brain regions. These data suggest that modulation of GABAergic transmission could be an important action of some antipsychotic drugs.
AB - The density of GABA(A) receptors in the hippocampus and the temporal cortex from rats treated for 28 days with either haloperidol, chlorpromazine, clozapine or olanzapine was measured. Compared to haloperidol (0.01 and 0.1 mg kg-1 day-1) and chlorpromazine (0.1 and 1 mg kg-1 day-1), clozapine and olanzapine (0.1 and 1 mg kg-1 day-1) markedly decreased the density of GABA(A) receptors in these two brain regions. These data suggest that modulation of GABAergic transmission could be an important action of some antipsychotic drugs.
KW - Antipsychotic
KW - GABA (γ-aminobutyric acid)
KW - Schizophrenia
UR - http://www.scopus.com/inward/record.url?scp=0032557590&partnerID=8YFLogxK
U2 - 10.1016/S0014-2999(98)00285-4
DO - 10.1016/S0014-2999(98)00285-4
M3 - Article
C2 - 9671088
AN - SCOPUS:0032557590
VL - 349
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -