Clozapine and olanzapine treatment decreases rat cortical and limbic GABA(A) receptors

Danièle Farnbach-Pralong, Robyn Bradbury, David Copolov, Brian Dean

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Abstract

The density of GABA(A) receptors in the hippocampus and the temporal cortex from rats treated for 28 days with either haloperidol, chlorpromazine, clozapine or olanzapine was measured. Compared to haloperidol (0.01 and 0.1 mg kg-1 day-1) and chlorpromazine (0.1 and 1 mg kg-1 day-1), clozapine and olanzapine (0.1 and 1 mg kg-1 day-1) markedly decreased the density of GABA(A) receptors in these two brain regions. These data suggest that modulation of GABAergic transmission could be an important action of some antipsychotic drugs.

Original languageEnglish
JournalEuropean Journal of Pharmacology
Volume349
Issue number2-3
DOIs
Publication statusPublished - 22 May 1998
Externally publishedYes

Keywords

  • Antipsychotic
  • GABA (γ-aminobutyric acid)
  • Schizophrenia

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