Closer association of IA-2 humoral autoreactivity with HLA DR3/4 than DQB1*0201/*0302 in Korean T1D patients

Yongsoo Park, Brian D. Tait, Eiji Kawasaki, Merrill Rowley, Ian R. Mackay

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5 Citations (Scopus)

Abstract

The HLA DQB1*0302 allele on DR4 haplotypes is a well-known marker for T1D susceptibility. The contribution of this DQ molecule to overall disease susceptibility may be genotype dependent. On Asian DR4 haplotypes, not only DQB1*0302, but also DQB1*0401 confer susceptibility to T1D, which is mediated by DRB1*0405 on the same haplotype. To analyze further the association of DQB1*0302 and DQB1*0401 haplotypes in Asian patients with T1D, we investigated HLA DR and DQ alleles with the presence or the persistence of GAD, ICA, and IA-2 autoantibodies in 121 Korean T1D patients. In Korean patients, there was an association of IA-2 autoantibedies with DR4 as well as DR3, but not with DQA1*0301-BQB1*0302. GAD autoantibodies were not associated with the DR3-DQB1*0201, DQA1*0301- DQB1*0302, or DR4. In this low-risk population, autoantibodies to islet-cell antigens were associated with different HLA molecules. In different populations, the immune response to different β cell autoantigens is mediated via varying HLA class II molecules from different loci. Design of the antigen-specific immunointervention trials should take into account such HLA DR and DQ association.

Original languageEnglish
Pages (from-to)104-109
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1037
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • GAD
  • HLA DQ
  • HLA DR
  • IA-2
  • Korea
  • T1D

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