Clonal T-helper lymphocytes and elevated IL-5 levels in episodic angioedema and eosinophilia (Gleich's syndrome)

Susan J. Morgan; H. Miles Prince; D. A.David A. Westerman; Christopher McCormack; Ian Glaspole

doi:10.1080/1042819031000083073

Clonal T-helper lymphocytes and elevated IL-5 levels in episodic angioedema and eosinophilia (Gleich's syndrome)

Susan J. Morgan, H. Miles Prince, D. A.David A. Westerman, Christopher McCormack, Ian Glaspole

Immunology Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

33 Citations (Scopus)

Abstract

A patient with marked chronic eosinophilia and episodic angioedema (Gleich's syndrome) with a concomitant clonal proliferation of helper T-lymphocytes is described. This association has not previously been documented. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement. However, the disease appears to have a similar pathogenesis, with elevated levels of the eosinophil-specific cytokine interleukin-5 (IL-5) produced by the T-cell clone.

Original language	English
Pages (from-to)	1623-1625
Number of pages	3
Journal	Leukemia and Lymphoma
Volume	44
Issue number	9
DOIs	https://doi.org/10.1080/1042819031000083073
Publication status	Published - 1 Sept 2003

Keywords

(IL-5)
Eosinophilia
Episodic angioedema
Interleukin-5
T-cell clonality

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/1042819031000083073

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abstract = "A patient with marked chronic eosinophilia and episodic angioedema (Gleich's syndrome) with a concomitant clonal proliferation of helper T-lymphocytes is described. This association has not previously been documented. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement. However, the disease appears to have a similar pathogenesis, with elevated levels of the eosinophil-specific cytokine interleukin-5 (IL-5) produced by the T-cell clone.",

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AU - Prince, H. Miles

AU - Westerman, D. A.David A.

AU - McCormack, Christopher

AU - Glaspole, Ian

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AB - A patient with marked chronic eosinophilia and episodic angioedema (Gleich's syndrome) with a concomitant clonal proliferation of helper T-lymphocytes is described. This association has not previously been documented. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement. However, the disease appears to have a similar pathogenesis, with elevated levels of the eosinophil-specific cytokine interleukin-5 (IL-5) produced by the T-cell clone.

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KW - Eosinophilia

KW - Episodic angioedema

KW - Interleukin-5

KW - T-cell clonality

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Clonal T-helper lymphocytes and elevated IL-5 levels in episodic angioedema and eosinophilia (Gleich's syndrome)

Abstract

Keywords

UN SDGs

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