Clonal T-helper lymphocytes and elevated IL-5 levels in episodic angioedema and eosinophilia (Gleich's syndrome)

Susan J. Morgan, H. Miles Prince, D. A.David A. Westerman, Christopher McCormack, Ian Glaspole

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A patient with marked chronic eosinophilia and episodic angioedema (Gleich's syndrome) with a concomitant clonal proliferation of helper T-lymphocytes is described. This association has not previously been documented. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement. However, the disease appears to have a similar pathogenesis, with elevated levels of the eosinophil-specific cytokine interleukin-5 (IL-5) produced by the T-cell clone.

Original languageEnglish
Pages (from-to)1623-1625
Number of pages3
JournalLeukemia and Lymphoma
Issue number9
Publication statusPublished - 1 Sept 2003


  • (IL-5)
  • Eosinophilia
  • Episodic angioedema
  • Interleukin-5
  • T-cell clonality

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