Clonal T-helper lymphocytes and elevated IL-5 levels in episodic angioedema and eosinophilia (Gleich's syndrome)

Susan J. Morgan, H. Miles Prince, D. A.David A. Westerman, Christopher McCormack, Ian Glaspole

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Abstract

A patient with marked chronic eosinophilia and episodic angioedema (Gleich's syndrome) with a concomitant clonal proliferation of helper T-lymphocytes is described. This association has not previously been documented. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement. However, the disease appears to have a similar pathogenesis, with elevated levels of the eosinophil-specific cytokine interleukin-5 (IL-5) produced by the T-cell clone.

Original languageEnglish
Pages (from-to)1623-1625
Number of pages3
JournalLeukemia and Lymphoma
Volume44
Issue number9
DOIs
Publication statusPublished - 1 Sep 2003

Keywords

  • (IL-5)
  • Eosinophilia
  • Episodic angioedema
  • Interleukin-5
  • T-cell clonality

Cite this