Clonal Blumea lacera (Burm. f.) DC. ameliorates diabetic conditions by modulating carbohydrate and lipid hydrolases: a combine in vivo experimental and chemico-biological interaction study

Mehedi Hasan, Md Monirul Islam, Md Obayed Raihan, Afrina Brishti, Avizit Das, Jakaria Shawon, Fariha Sultana, Md Wasim Bari, Mohammad Amirul Islam, Siew Hua Gan, A. M. Swaraz

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Blumea lacera (Burm. f.) DC. is an aromatic annual herb that has traditionally been used to treat or protect against diabetes. Although it has infallible uses, its supply is limited due to its short lifespan. In this study, we aim to investigate the anti-diabetic potential of its micropropagated plants in type 2 diabetic mammalian (mouse) model and further expand the molecular mechanistic understanding of its activity. The water extract of the micropropagated plants was tested in mice with streptozotocin-induced diabetes. The extract effectively suppressed glucose levels prevented weight loss, and improved dyslipidemia in mice. Additionally, it improved liver injury as well as all investigated toxicity indicators, including serum glutamate-pyruvate transaminase, serum glutamic oxaloacetic transaminase, and serum anti-inflammatory marker C-reactive protein. The intramolecular interaction study revealed that the innate polyphenolic constituents of this plant more profoundly inhibited α-amylase, α-glucosidase, and lipase compared to the standard. The prolific bioactive compounds of the micropropagated plant could be attributed to these superior anti-diabetic effects, presumably via an elaborate inhibition of carbohydrate and lipid hydrolyzing enzymes. Thus, the obtained results provide solid experimental proof of the year-round utility of micropropagated plants as a standard source plant material of Blumea lacera (Burm. f.) DC. for drug research and therapeutic production.

Original languageEnglish
Article number152
Number of pages13
Journal3 Biotech
Volume13
Issue number5
DOIs
Publication statusPublished - 29 Apr 2023

Keywords

  • Blumea lacera
  • Carbohydrate and lipid hydrolase
  • In vitro regenerated plant
  • Molecular docking
  • Streptozotocin
  • Type 2 diabetes

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