TY - JOUR
T1 - Clinicopathologic and prognostic roles of circular RNA plasmacytoma variant translocation 1 in various cancers
AU - Zhou, Jian
AU - Zhang, Hui
AU - Zou, Dazhi
AU - Zhou, Zhen
AU - Wang, Wanchun
AU - Luo, Yingquan
AU - Liu, Tang
N1 - Funding Information:
This work was supported by the Fundamental Research Funds for the Central Universities of Central South University [Grant No. 2018zzts930]. The authors would like to thank Dr. Ayub Abdulle nur and Dr. Zhen Zhou for English language support in this manuscript.
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2021/10/3
Y1 - 2021/10/3
N2 - Objective: To explore the clinicopathologic and prognostic significance of circular RNA plasmacytoma variant translocation 1 (circPVT1) in various cancers. Methods: Several databases were searched for eligible studies published before March 01, 2021. The pooled odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to assess the association between circPVT1 expression and prognostic outcomes of tumor including age, gender, clinical stage, tumor size, metastasis and overall survival. Begg’s funnel plots and Egger’s test were used to evaluate the publication bias. The robustness of our results was assessed using sensitivity analysis. Results: Ten studies comprising a total of 878 patients with cancer were included in this meta-analysis. The results showed that the high expression of circPVT1 was significantly related to clinical stage (OR=3.44, 95% CI: 2.40-4.94, P<0.05), tumor size (OR=2.29, 95% CI: 1.38-3.79, P<0.05), metastasis (OR=2.97, 95% CI: 2.06-4.28, p<0.05) and overall survival of cancer (OR=3.30, 95% CI: 2.26-4.84, p<0.05), but not associated with age and gender of patients with tumor. No publication bias was found. Conclusions: High expression of circPVT1 may predict an advanced clinical stage and poor prognosis of tumor, suggesting that circPVT1 may serve as a potential prognostic marker in cancers. .
AB - Objective: To explore the clinicopathologic and prognostic significance of circular RNA plasmacytoma variant translocation 1 (circPVT1) in various cancers. Methods: Several databases were searched for eligible studies published before March 01, 2021. The pooled odds ratios (ORs) with 95% confidence interval (95% CI) were calculated to assess the association between circPVT1 expression and prognostic outcomes of tumor including age, gender, clinical stage, tumor size, metastasis and overall survival. Begg’s funnel plots and Egger’s test were used to evaluate the publication bias. The robustness of our results was assessed using sensitivity analysis. Results: Ten studies comprising a total of 878 patients with cancer were included in this meta-analysis. The results showed that the high expression of circPVT1 was significantly related to clinical stage (OR=3.44, 95% CI: 2.40-4.94, P<0.05), tumor size (OR=2.29, 95% CI: 1.38-3.79, P<0.05), metastasis (OR=2.97, 95% CI: 2.06-4.28, p<0.05) and overall survival of cancer (OR=3.30, 95% CI: 2.26-4.84, p<0.05), but not associated with age and gender of patients with tumor. No publication bias was found. Conclusions: High expression of circPVT1 may predict an advanced clinical stage and poor prognosis of tumor, suggesting that circPVT1 may serve as a potential prognostic marker in cancers. .
KW - cancers
KW - CircPVT1
KW - clinical features
KW - meta-analysis
KW - prognosis
UR - http://www.scopus.com/inward/record.url?scp=85113749764&partnerID=8YFLogxK
U2 - 10.1080/14737159.2021.1964959
DO - 10.1080/14737159.2021.1964959
M3 - Article
C2 - 34346262
AN - SCOPUS:85113749764
SN - 1473-7159
VL - 21
SP - 1095
EP - 1104
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
IS - 10
ER -
