Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant peudomonas aeruginosa at multiple inocula

Phillip Bergen, Alan Forrest, Jurgen Bulitta, Brian Tsuji, Hanna Sidjabat, David Paterson, Jian Li, Roger Nation

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Abstract

The use of combination antibiotic therapy may be beneficial against rapidly emerging resistance in Pseudomonas aeruginosa. The aim of this study was to systematically investigate in vitro bacterial killing and resistance emergence with colistin alone and in combination with imipenem against multidrug-resistant (MDR)
Original languageEnglish
Pages (from-to)5134 - 5142
Number of pages9
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number11
DOIs
Publication statusPublished - 2011

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