Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease

Melissa Haines; Yousef Ajlouni; Peter Irving; Miles Sparrow; Rosemary Rose; Richard Gearry; Peter Gibson

doi:10.1002/ibd.21458

Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease

Melissa Haines, Yousef Ajlouni, Peter Irving, Miles Sparrow, Rosemary Rose, Richard Gearry, Peter Gibson

Eastern Health Clinical School

Research output: Contribution to journal › Article › Research › peer-review

80 Citations (Scopus)

Abstract

Concentrations of 6-TGN and 6-MMP were measured in lysates of washed red cells by high-performance liquid chromatography in peripheral blood drawn from 63 symptomatic patients with IBD (63 men, mean age 37, range 14-74 years, 67 Crohn s disease, 33 ulcerative colitis) treated with azathioprine or 6-mercaptopurine. Short-term clinical outcomes were examined.

Original language	English
Pages (from-to)	1301 - 1307
Number of pages	6
Journal	Inflammatory Bowel Diseases
Volume	17
DOIs	https://doi.org/10.1002/ibd.21458
Publication status	Published - 2011

Access to Document

10.1002/ibd.21458

Cite this

@article{addde54efffc4ea7b07f1bb6c7a05687,

title = "Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease",

abstract = "Concentrations of 6-TGN and 6-MMP were measured in lysates of washed red cells by high-performance liquid chromatography in peripheral blood drawn from 63 symptomatic patients with IBD (63 men, mean age 37, range 14-74 years, 67 Crohn s disease, 33 ulcerative colitis) treated with azathioprine or 6-mercaptopurine. Short-term clinical outcomes were examined.",

author = "Melissa Haines and Yousef Ajlouni and Peter Irving and Miles Sparrow and Rosemary Rose and Richard Gearry and Peter Gibson",

year = "2011",

doi = "10.1002/ibd.21458",

language = "English",

volume = "17",

pages = "1301 -- 1307",

journal = "Inflammatory Bowel Diseases",

issn = "1078-0998",

publisher = "Oxford University Press, USA",

}

TY - JOUR

T1 - Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease

AU - Haines, Melissa

AU - Ajlouni, Yousef

AU - Irving, Peter

AU - Sparrow, Miles

AU - Rose, Rosemary

AU - Gearry, Richard

AU - Gibson, Peter

PY - 2011

Y1 - 2011

N2 - Concentrations of 6-TGN and 6-MMP were measured in lysates of washed red cells by high-performance liquid chromatography in peripheral blood drawn from 63 symptomatic patients with IBD (63 men, mean age 37, range 14-74 years, 67 Crohn s disease, 33 ulcerative colitis) treated with azathioprine or 6-mercaptopurine. Short-term clinical outcomes were examined.

AB - Concentrations of 6-TGN and 6-MMP were measured in lysates of washed red cells by high-performance liquid chromatography in peripheral blood drawn from 63 symptomatic patients with IBD (63 men, mean age 37, range 14-74 years, 67 Crohn s disease, 33 ulcerative colitis) treated with azathioprine or 6-mercaptopurine. Short-term clinical outcomes were examined.

UR - http://onlinelibrary.wiley.com/doi/10.1002/ibd.21458/pdf

U2 - 10.1002/ibd.21458

DO - 10.1002/ibd.21458

M3 - Article

VL - 17

SP - 1301

EP - 1307

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

ER -

Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease

Abstract

Access to Document

Other files and links

Cite this