Clinical usefulness of therapeutic drug monitoring of thiopurines in patients with inadequately controlled inflammatory bowel disease

Melissa Haines, Yousef Ajlouni, Peter Irving, Miles Sparrow, Rosemary Rose, Richard Gearry, Peter Gibson

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80 Citations (Scopus)


Concentrations of 6-TGN and 6-MMP were measured in lysates of washed red cells by high-performance liquid chromatography in peripheral blood drawn from 63 symptomatic patients with IBD (63 men, mean age 37, range 14-74 years, 67 Crohn s disease, 33 ulcerative colitis) treated with azathioprine or 6-mercaptopurine. Short-term clinical outcomes were examined.
Original languageEnglish
Pages (from-to)1301 - 1307
Number of pages6
JournalInflammatory Bowel Diseases
Publication statusPublished - 2011

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