Clinical trials for stem cell therapies

Alan Trounson, Rahul G. Thakar, Geoff Lomax, Don Gibbons

Research output: Contribution to journalReview ArticleResearchpeer-review

312 Citations (Scopus)

Abstract

In recent years, clinical trials with stem cells have taken the emerging field in many new directions. While numerous teams continue to refine and expand the role of bone marrow and cord blood stem cells for their vanguard uses in blood and immune disorders, many others are looking to expand the uses of the various types of stem cells found in bone marrow and cord blood, in particular mesenchymal stem cells, to uses beyond those that could be corrected by replacing cells in their own lineage. Early results from these trials have produced mixed results often showing minor or transitory improvements that may be attributed to extracellular factors. More research teams are accelerating the use of other types of adult stem cells, in particular neural stem cells for diseases where beneficial outcome could result from either in-lineage cell replacement or extracellular factors. At the same time, the first three trials using cells derived from pluripotent cells have begun.

Original languageEnglish
Article number52
JournalBMC Medicine
Volume9
DOIs
Publication statusPublished - 10 May 2011
Externally publishedYes

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