Clinical Trial Protocol for LuTectomy: A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of 177Lu-PSMA-617 Prior to Prostatectomy

Nattakorn Dhiantravan; John Violet; Renu Eapen; Omar Alghazo; Mark Scalzo; Price Jackson; Simon P. Keam; Catherine Mitchell; Paul J. Neeson; Shahneen Sandhu; Scott G. Williams; Daniel Moon; Nathan Lawrentschuk; Arun Azad; Michael S. Hofman; Declan G. Murphy

doi:10.1016/j.euf.2020.09.021

Clinical Trial Protocol for LuTectomy: A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of ¹⁷⁷Lu-PSMA-617 Prior to Prostatectomy

Nattakorn Dhiantravan, John Violet, Renu Eapen, Omar Alghazo, Mark Scalzo, Price Jackson, Simon P. Keam, Catherine Mitchell, Paul J. Neeson, Shahneen Sandhu, Scott G. Williams, Daniel Moon, Nathan Lawrentschuk, Arun Azad, Michael S. Hofman, Declan G. Murphy

Research output: Contribution to journal › Article › Other › peer-review

Abstract

LuTectomy is an open-label phase 1/2 nonrandomised clinical trial evaluating the dosimetry, efficacy, and toxicity of the lutetium-177–radiolabelled small molecule PSMA-617 in men with high-risk localised/locoregional advanced prostate cancer with high prostate-specific membrane antigen expression who are undergoing radical prostatectomy and pelvic lymph node dissection.

Original language	English
Number of pages	4
Journal	European Urology Focus
DOIs	https://doi.org/10.1016/j.euf.2020.09.021
Publication status	Accepted/In press - 7 Nov 2020
Externally published	Yes

Access to Document

10.1016/j.euf.2020.09.021

Link to publication in Scopus

Cite this

Dhiantravan, N., Violet, J., Eapen, R., Alghazo, O., Scalzo, M., Jackson, P., Keam, S. P., Mitchell, C., Neeson, P. J., Sandhu, S., Williams, S. G., Moon, D., Lawrentschuk, N., Azad, A., Hofman, M. S., & Murphy, D. G. (Accepted/In press). Clinical Trial Protocol for LuTectomy: A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of ¹⁷⁷Lu-PSMA-617 Prior to Prostatectomy. European Urology Focus. https://doi.org/10.1016/j.euf.2020.09.021

Dhiantravan, Nattakorn ; Violet, John ; Eapen, Renu ; Alghazo, Omar ; Scalzo, Mark ; Jackson, Price ; Keam, Simon P. ; Mitchell, Catherine ; Neeson, Paul J. ; Sandhu, Shahneen ; Williams, Scott G. ; Moon, Daniel ; Lawrentschuk, Nathan ; Azad, Arun ; Hofman, Michael S. ; Murphy, Declan G. / Clinical Trial Protocol for LuTectomy : A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of ¹⁷⁷Lu-PSMA-617 Prior to Prostatectomy. In: European Urology Focus. 2020.

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title = "Clinical Trial Protocol for LuTectomy: A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of 177Lu-PSMA-617 Prior to Prostatectomy",

abstract = "LuTectomy is an open-label phase 1/2 nonrandomised clinical trial evaluating the dosimetry, efficacy, and toxicity of the lutetium-177–radiolabelled small molecule PSMA-617 in men with high-risk localised/locoregional advanced prostate cancer with high prostate-specific membrane antigen expression who are undergoing radical prostatectomy and pelvic lymph node dissection.",

author = "Nattakorn Dhiantravan and John Violet and Renu Eapen and Omar Alghazo and Mark Scalzo and Price Jackson and Keam, {Simon P.} and Catherine Mitchell and Neeson, {Paul J.} and Shahneen Sandhu and Williams, {Scott G.} and Daniel Moon and Nathan Lawrentschuk and Arun Azad and Hofman, {Michael S.} and Murphy, {Declan G.}",

year = "2020",

month = nov,

day = "7",

doi = "10.1016/j.euf.2020.09.021",

language = "English",

journal = "European Urology Focus",

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Dhiantravan, N, Violet, J, Eapen, R, Alghazo, O, Scalzo, M, Jackson, P, Keam, SP, Mitchell, C, Neeson, PJ, Sandhu, S, Williams, SG, Moon, D, Lawrentschuk, N, Azad, A, Hofman, MS & Murphy, DG 2020, 'Clinical Trial Protocol for LuTectomy: A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of ¹⁷⁷Lu-PSMA-617 Prior to Prostatectomy', European Urology Focus. https://doi.org/10.1016/j.euf.2020.09.021

Clinical Trial Protocol for LuTectomy : A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of ¹⁷⁷Lu-PSMA-617 Prior to Prostatectomy. / Dhiantravan, Nattakorn; Violet, John; Eapen, Renu; Alghazo, Omar; Scalzo, Mark; Jackson, Price; Keam, Simon P.; Mitchell, Catherine; Neeson, Paul J.; Sandhu, Shahneen; Williams, Scott G.; Moon, Daniel; Lawrentschuk, Nathan; Azad, Arun; Hofman, Michael S.; Murphy, Declan G.

In: European Urology Focus, 07.11.2020.

Research output: Contribution to journal › Article › Other › peer-review

TY - JOUR

T1 - Clinical Trial Protocol for LuTectomy

T2 - A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of 177Lu-PSMA-617 Prior to Prostatectomy

AU - Dhiantravan, Nattakorn

AU - Violet, John

AU - Eapen, Renu

AU - Alghazo, Omar

AU - Scalzo, Mark

AU - Jackson, Price

AU - Keam, Simon P.

AU - Mitchell, Catherine

AU - Neeson, Paul J.

AU - Sandhu, Shahneen

AU - Williams, Scott G.

AU - Moon, Daniel

AU - Lawrentschuk, Nathan

AU - Azad, Arun

AU - Hofman, Michael S.

AU - Murphy, Declan G.

PY - 2020/11/7

Y1 - 2020/11/7

N2 - LuTectomy is an open-label phase 1/2 nonrandomised clinical trial evaluating the dosimetry, efficacy, and toxicity of the lutetium-177–radiolabelled small molecule PSMA-617 in men with high-risk localised/locoregional advanced prostate cancer with high prostate-specific membrane antigen expression who are undergoing radical prostatectomy and pelvic lymph node dissection.

AB - LuTectomy is an open-label phase 1/2 nonrandomised clinical trial evaluating the dosimetry, efficacy, and toxicity of the lutetium-177–radiolabelled small molecule PSMA-617 in men with high-risk localised/locoregional advanced prostate cancer with high prostate-specific membrane antigen expression who are undergoing radical prostatectomy and pelvic lymph node dissection.

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DO - 10.1016/j.euf.2020.09.021

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JO - European Urology Focus

JF - European Urology Focus

SN - 2405-4569

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