Abstract
Objective To investigate clinical symptoms, cognitive performance and cortical activity following mild traumatic brain injury (mTBI).
Methods Thirty individuals in the sub-acute phase post mTBI and 28 healthy controls with no history of head injury were compared on clinical, cognitive and cortical activity measures. Measures of cortical activity included; resting state EEG, task related EEG and combined transcranial magnetic stimulation with electroencephalography (TMS-EEG). Primary analyses investigated clinical, cognitive and cortical activity differences between groups. Exploratory analyses investigated the relationships between these measures.
Results At 4 weeks’ post injury, mTBI participants exhibited significantly greater post concussive and clinical symptoms compared to controls; as well as reduced cognitive performance on verbal learning and working memory measures. mTBI participants demonstrated alterations in cortical activity while at rest and in response to stimulation with TMS.
Conclusions The mTBI group demonstrated neurophysiological markers of altered excitatory and inhibitory processes which impact neural function. Further research is needed to explore the relationship between these pathophysiologies and clinical/cognitive symptoms in mTBI.
Methods Thirty individuals in the sub-acute phase post mTBI and 28 healthy controls with no history of head injury were compared on clinical, cognitive and cortical activity measures. Measures of cortical activity included; resting state EEG, task related EEG and combined transcranial magnetic stimulation with electroencephalography (TMS-EEG). Primary analyses investigated clinical, cognitive and cortical activity differences between groups. Exploratory analyses investigated the relationships between these measures.
Results At 4 weeks’ post injury, mTBI participants exhibited significantly greater post concussive and clinical symptoms compared to controls; as well as reduced cognitive performance on verbal learning and working memory measures. mTBI participants demonstrated alterations in cortical activity while at rest and in response to stimulation with TMS.
Conclusions The mTBI group demonstrated neurophysiological markers of altered excitatory and inhibitory processes which impact neural function. Further research is needed to explore the relationship between these pathophysiologies and clinical/cognitive symptoms in mTBI.
| Original language | English |
|---|---|
| Type | preprint |
| Publisher | medRxiv |
| Number of pages | 36 |
| DOIs | |
| Publication status | Published - Jun 2022 |