Clinical proteomics-driven precision medicine for targeted cancer therapy: Current overview and future perspectives

Li Zhou, Kui Wang, Qifu Li, Edouard C. Nice, Haiyuan Zhang, Canhua Huang

Research output: Contribution to journalReview ArticleResearchpeer-review

28 Citations (Scopus)

Abstract

Cancer is a common disease that is a leading cause of death worldwide. Currently, early detection and novel therapeutic strategies are urgently needed for more effective management of cancer. Importantly, protein profiling using clinical proteomic strategies, with spectacular sensitivity and precision, offer excellent promise for the identification of potential biomarkers that would direct the development of targeted therapeutic anticancer drugs for precision medicine. In particular, clinical sample sources, including tumor tissues and body fluids (blood, feces, urine and saliva), have been widely investigated using modern high-throughput mass spectrometry-based proteomic approaches combined with bioinformatic analysis, to pursue the possibilities of precision medicine for targeted cancer therapy. Discussed in this review are the current advantages and limitations of clinical proteomics, the available strategies of clinical proteomics for the management of precision medicine, as well as the challenges and future perspectives of clinical proteomics-driven precision medicine for targeted cancer therapy.
Original languageEnglish
Pages (from-to)367-381
Number of pages15
JournalExpert Review of Proteomics
Volume13
Issue number4
DOIs
Publication statusPublished - 16 Mar 2016

Keywords

  • clinical proteomics
  • precision medicine
  • cancer therapy
  • mass spectrometry
  • drug target identification

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