Clinical phenotypes and outcome of patients hospitalized for acute heart failure: The ESC Heart Failure Long-Term Registry

Ovidiu Chioncel, Alexandre Mebazaa, Veli-Pekka Harjola, Andrew J. Coats, Massimo Francesco Piepoli, Maria G. Crespo-Leiro, Cecile Laroche, Petar M. Seferovic, Stefan D. Anker, Roberto Ferrari, Frank Ruschitzka, Silvia Lopez-Fernandez, Daniela Miani, Gerasimos Filippatos, Aldo P. Maggioni

    Research output: Contribution to journalArticleResearchpeer-review

    326 Citations (Scopus)


    Aims: To identify differences in clinical epidemiology, in-hospital management and 1-year outcomes among patients hospitalized for acute heart failure (AHF) and enrolled in the European Society of Cardiology Heart Failure Long-Term (ESC-HF-LT) Registry, stratified by clinical profile at admission. Methods and results: The ESC-HF-LT Registry is a prospective, observational study collecting hospitalization and 1-year follow-up data from 6629 AHF patients. Among AHF patients enrolled in the registry, 13.2% presented with pulmonary oedema (PO), 2.9% with cardiogenic shock (CS), 61.1% with decompensated heart failure (DHF), 4.8% with hypertensive heart failure (HT-HF), 3.5% with right heart failure (RHF) and 14.4% with AHF and associated acute coronary syndromes (ACS-HF). The 1-year mortality rate was 28.1% in PO, 54.0% in CS, 27.2% in DHF, 12.8% in HT-HF, 34.0% in RHF and 20.6% in ACS-HF patients. When patients were classified by systolic blood pressure (SBP) at initial presentation, 1-year mortality was 34.8% in patients with SBP <85 mmHg, 29.0% in those with SBP 85-110 mmHg, 21.2% in patients with SBP 110-140 mmHg and 17.4% in those with SBP >140 mmHg. These differences tended to diminish in the months post-discharge, and 1-year mortality for the patients who survived at least 6 months post-discharge did not vary significantly by either clinical profile or SBP classification. Conclusion: Rates of adverse outcomes in AHF remain high, and substantial differences have been found when patients were stratified by clinical profile or SBP. However, patients who survived at least 6 months post-discharge represent a more homogeneous group and their 1-year outcome is less influenced by clinical profile or SBP at admission.

    Original languageEnglish
    Pages (from-to)1242-1254
    Number of pages13
    JournalEuropean Journal of Heart Failure
    Issue number10
    Publication statusPublished - 1 Oct 2017


    • Acute heart failure
    • Clinical profile
    • Outcomes

    Cite this