Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: A study by the asian network for surveillance of resistant pathogens

Jae Hoon Song; Sook In Jung; Hyun Kyim Ki; Myung Hee Shin; Kwan Soo Ko; Jun Seong Son; Hyun Ha Chang; Shin Woo Kim; Hyuck Lee; Yeon Sook Kim; Won Sup Oh; Kyong Ran Peck; Anan Chongthaleong; M. K. Lalitha; Jennifer Perera; Ti Teow Yee; Farida Jamal; Adeeba Kamarulzaman; Celia C. Carlos; Thomas So; for the Asian Network for Surveillance of Resistant Pathogens Study Group

doi:10.1086/420821

Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: A study by the asian network for surveillance of resistant pathogens

Jae Hoon Song, Sook In Jung, Hyun Kyim Ki, Myung Hee Shin, Kwan Soo Ko, Jun Seong Son, Hyun Ha Chang, Shin Woo Kim, Hyuck Lee, Yeon Sook Kim, Won Sup Oh, Kyong Ran Peck, Anan Chongthaleong, M. K. Lalitha, Jennifer Perera, Ti Teow Yee, Farida Jamal, Adeeba Kamarulzaman, Celia C. Carlos, Thomas Sofor the Asian Network for Surveillance of Resistant Pathogens Study Group

Research output: Contribution to journal › Article › Research › peer-review

95 Citations (Scopus)

Abstract

To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from January 2000 to June 2001. Among 233 isolates, 128 (55%) were not susceptible to penicillin (25.3% were intermediately susceptible, and 29.6% were resistant). Clinical severity of pneumococcal pneumonia was not significantly different between antibiotic-resistant and antibiotic-susceptible groups. Mortality rates among patients with pneumococcal pneumonia caused by penicillin-, cephalosporin-, or macrolide-resistant strains were not higher than those with antibiotic-susceptible pneumococcal pneumonia. Bacteremia and mechanical ventilation were significant risk factors for death, but any kind of antibiotic resistance was not associated with increased mortality due to pneumococcal pneumonia. Outcome of pneumococcal pneumonia was not significantly affected by drug resistance, and current antimicrobial regimens are mostly effective in the treatment of pneumococcal pneumonia, despite the widespread emergence of in vitro resistance.

Original language	English
Pages (from-to)	1570-1578
Number of pages	9
Journal	Clinical Infectious Diseases
Volume	38
Issue number	11
DOIs	https://doi.org/10.1086/420821
Publication status	Published - 1 Jun 2004
Externally published	Yes

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10.1086/420821

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Song, J. H., Jung, S. I., Ki, H. K., Shin, M. H., Ko, K. S., Son, J. S., Chang, H. H., Kim, S. W., Lee, H., Kim, Y. S., Oh, W. S., Peck, K. R., Chongthaleong, A., Lalitha, M. K., Perera, J., Yee, T. T., Jamal, F., Kamarulzaman, A., Carlos, C. C., ... for the Asian Network for Surveillance of Resistant Pathogens Study Group (2004). Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: A study by the asian network for surveillance of resistant pathogens. Clinical Infectious Diseases, 38(11), 1570-1578. https://doi.org/10.1086/420821

@article{b58ee01ce8414a518469820c147995d6,

title = "Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: A study by the asian network for surveillance of resistant pathogens",

abstract = "To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from January 2000 to June 2001. Among 233 isolates, 128 (55\%) were not susceptible to penicillin (25.3\% were intermediately susceptible, and 29.6\% were resistant). Clinical severity of pneumococcal pneumonia was not significantly different between antibiotic-resistant and antibiotic-susceptible groups. Mortality rates among patients with pneumococcal pneumonia caused by penicillin-, cephalosporin-, or macrolide-resistant strains were not higher than those with antibiotic-susceptible pneumococcal pneumonia. Bacteremia and mechanical ventilation were significant risk factors for death, but any kind of antibiotic resistance was not associated with increased mortality due to pneumococcal pneumonia. Outcome of pneumococcal pneumonia was not significantly affected by drug resistance, and current antimicrobial regimens are mostly effective in the treatment of pneumococcal pneumonia, despite the widespread emergence of in vitro resistance.",

author = "Song, \{Jae Hoon\} and Jung, \{Sook In\} and Ki, \{Hyun Kyim\} and Shin, \{Myung Hee\} and Ko, \{Kwan Soo\} and Son, \{Jun Seong\} and Chang, \{Hyun Ha\} and Kim, \{Shin Woo\} and Hyuck Lee and Kim, \{Yeon Sook\} and Oh, \{Won Sup\} and Peck, \{Kyong Ran\} and Anan Chongthaleong and Lalitha, \{M. K.\} and Jennifer Perera and Yee, \{Ti Teow\} and Farida Jamal and Adeeba Kamarulzaman and Carlos, \{Celia C.\} and Thomas So and \{for the Asian Network for Surveillance of Resistant Pathogens Study Group\}",

note = "Funding Information: Financial support: Bayer Healthcare (Wuppertal, Germany); and Samsung Biomedical Research Institute (grant C-A3-214-1), Samsung Medical Center, and the Asian-Pacific Research Foundation for Infectious Diseases (Seoul, Korea).",

year = "2004",

month = jun,

day = "1",

doi = "10.1086/420821",

language = "English",

volume = "38",

pages = "1570--1578",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press, USA",

number = "11",

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Song, JH, Jung, SI, Ki, HK, Shin, MH, Ko, KS, Son, JS, Chang, HH, Kim, SW, Lee, H, Kim, YS, Oh, WS, Peck, KR, Chongthaleong, A, Lalitha, MK, Perera, J, Yee, TT, Jamal, F, Kamarulzaman, A, Carlos, CC, So, T & for the Asian Network for Surveillance of Resistant Pathogens Study Group 2004, 'Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: A study by the asian network for surveillance of resistant pathogens', Clinical Infectious Diseases, vol. 38, no. 11, pp. 1570-1578. https://doi.org/10.1086/420821

Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: A study by the asian network for surveillance of resistant pathogens. / Song, Jae Hoon; Jung, Sook In; Ki, Hyun Kyim et al.
In: Clinical Infectious Diseases, Vol. 38, No. 11, 01.06.2004, p. 1570-1578.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries

T2 - A study by the asian network for surveillance of resistant pathogens

AU - Song, Jae Hoon

AU - Jung, Sook In

AU - Ki, Hyun Kyim

AU - Shin, Myung Hee

AU - Ko, Kwan Soo

AU - Son, Jun Seong

AU - Chang, Hyun Ha

AU - Kim, Shin Woo

AU - Lee, Hyuck

AU - Kim, Yeon Sook

AU - Oh, Won Sup

AU - Peck, Kyong Ran

AU - Chongthaleong, Anan

AU - Lalitha, M. K.

AU - Perera, Jennifer

AU - Yee, Ti Teow

AU - Jamal, Farida

AU - Kamarulzaman, Adeeba

AU - Carlos, Celia C.

AU - So, Thomas

AU - for the Asian Network for Surveillance of Resistant Pathogens Study Group

N1 - Funding Information: Financial support: Bayer Healthcare (Wuppertal, Germany); and Samsung Biomedical Research Institute (grant C-A3-214-1), Samsung Medical Center, and the Asian-Pacific Research Foundation for Infectious Diseases (Seoul, Korea).

PY - 2004/6/1

Y1 - 2004/6/1

N2 - To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from January 2000 to June 2001. Among 233 isolates, 128 (55%) were not susceptible to penicillin (25.3% were intermediately susceptible, and 29.6% were resistant). Clinical severity of pneumococcal pneumonia was not significantly different between antibiotic-resistant and antibiotic-susceptible groups. Mortality rates among patients with pneumococcal pneumonia caused by penicillin-, cephalosporin-, or macrolide-resistant strains were not higher than those with antibiotic-susceptible pneumococcal pneumonia. Bacteremia and mechanical ventilation were significant risk factors for death, but any kind of antibiotic resistance was not associated with increased mortality due to pneumococcal pneumonia. Outcome of pneumococcal pneumonia was not significantly affected by drug resistance, and current antimicrobial regimens are mostly effective in the treatment of pneumococcal pneumonia, despite the widespread emergence of in vitro resistance.

AB - To evaluate the clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries, we performed a prospective observational study of 233 cases of adult pneumococcal pneumonia in 9 Asian countries from January 2000 to June 2001. Among 233 isolates, 128 (55%) were not susceptible to penicillin (25.3% were intermediately susceptible, and 29.6% were resistant). Clinical severity of pneumococcal pneumonia was not significantly different between antibiotic-resistant and antibiotic-susceptible groups. Mortality rates among patients with pneumococcal pneumonia caused by penicillin-, cephalosporin-, or macrolide-resistant strains were not higher than those with antibiotic-susceptible pneumococcal pneumonia. Bacteremia and mechanical ventilation were significant risk factors for death, but any kind of antibiotic resistance was not associated with increased mortality due to pneumococcal pneumonia. Outcome of pneumococcal pneumonia was not significantly affected by drug resistance, and current antimicrobial regimens are mostly effective in the treatment of pneumococcal pneumonia, despite the widespread emergence of in vitro resistance.

UR - https://www.scopus.com/pages/publications/2942534184

U2 - 10.1086/420821

DO - 10.1086/420821

M3 - Article

C2 - 15156445

AN - SCOPUS:2942534184

SN - 1058-4838

VL - 38

SP - 1570

EP - 1578

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 11

ER -

Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in asian countries: A study by the asian network for surveillance of resistant pathogens

Abstract

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Erratum: Asian Network for Surveillance of Resistant Pathogens Study Group. Clinical outcomes of pneumococcal pneumonia caused by antibiotic-resistant strains in Asian countries: A study by the Asian Network for Surveillance of Resistant Pathogens (Clinical Infectious Diseases (2004) 38 (1570-1578))

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