TY - JOUR
T1 - Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma
AU - Devitt, Bianca
AU - Liu, Wendy
AU - Salemi, Renato
AU - Wolfe, Rory
AU - Kelly, John
AU - Tzen, Chin-Yuan
AU - Dobrovic, Alexander
AU - McArthur, Grant
PY - 2011
Y1 - 2011
N2 - This study has shown that mutations in BRAFV600E and NRAS confer distinct pathological characteristics, which translate into worse clinical outcomes. If this finding is verified in other prospective observational studies, mutation status should be routinely included as a stratification factor in adjuvant clinical trials. This study highlights the need for further molecular classification of melanoma to understand how mutations in BRAFV600E and NRAS interact with other, as yet, undiscovered mutations so that further targeted therapies can be developed.
AB - This study has shown that mutations in BRAFV600E and NRAS confer distinct pathological characteristics, which translate into worse clinical outcomes. If this finding is verified in other prospective observational studies, mutation status should be routinely included as a stratification factor in adjuvant clinical trials. This study highlights the need for further molecular classification of melanoma to understand how mutations in BRAFV600E and NRAS interact with other, as yet, undiscovered mutations so that further targeted therapies can be developed.
UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1755-148X.2011.00873.x/pdf
U2 - 10.1111/j.1755-148X.2011.00873.x
DO - 10.1111/j.1755-148X.2011.00873.x
M3 - Article
SN - 1755-1471
VL - 24
SP - 666
EP - 672
JO - Pigment Cell and Melanoma Research
JF - Pigment Cell and Melanoma Research
IS - 4
ER -