Clinical, microbiological, and economic benefit of a change in antibiotic prophylaxis for cardiac surgery

Denis Spelman, Glenys Harrington, Phil Russo, S. Wesselingh

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38 Citations (Scopus)


Vancomycin and rifampicin replaced cephazolin as antibiotic prophylaxis for coronary artery bypass surgery at our institution. Following this intervention, there was a significant decrease (P < .001) in the surgical-site infection rate from 10.5 (95% confidence interval, 8.2 to 13.3) to 4.9 (95% confidence interval, 3.2 to 7.1) infections per 100 procedures. An estimated $576,655 (Australian) was saved between two 12-month periods.

Original languageEnglish
Pages (from-to)402-404
Number of pages3
JournalInfection Control & Hospital Epidemiology
Issue number7
Publication statusPublished - 1 Jan 2002

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