Abstract
Three AIDS patients with severe cutaneous herpes simplex virus (HSV) infection refractory to therapy with acyclovir and foscarnet (2 patients) were treated with a topical preparation of trifluorothymidine (TFT) and interferon-α. Complete healing of lesions occurred in 1 patient; a second had significant regression of the infected area. In the third, the lesion was stabilized twice after application of the preparation and reduced in size after a subsequent treatment. In vitro studies confirmed that isolates from these patients were acyclovir- or acyclovir/foscarnet- resistant. In addition, they revealed strong synergy between TFT and interferon-α for these isolates and for strains with wild-type drug sensitivity profiles. Topical TFT/interferon-α may be of benefit in the therapy of mucocutaneous HSV infections, especially when they are resistant to treatment with systemic antiviral agents.
Original language | English |
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Pages (from-to) | 108-112 |
Number of pages | 5 |
Journal | The Journal of Infectious Diseases |
Volume | 166 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 1992 |
Externally published | Yes |