@article{b7a54329755c4dd8a74070f39f394865,
title = "Clinical correlates and outcomes associated with pregabalin use among people prescribed opioids for chronic non-cancer pain: A five-year prospective cohort study",
abstract = "Aims: Pregabalin has become widely used as an alternative to opioids in treating certain types of chronic non-cancer pain, but few studies have examined its clinical efficacy outside trials. We address this gap by examining the utilization, correlates and clinical outcomes of pregabalin use among an Australian community-based cohort of people prescribed opioids for chronic non-cancer pain. Methods: Through a five-year prospective cohort study (n = 1514) we examined associations between pregabalin use and pain severity and interference, mental health, opioid dose and past month use of ambulance and emergency department services. We used fixed-effects regression models to examine within-participant differences, and random-effects regression models to examine within- and between-participant differences in clinical outcomes. Results: In an analysis of cases with complete data over five-years (n = 896), the prevalence of pregabalin use ranged from 16% at cohort entry to 29% at 36- and 48-months, and 46% reported pregabalin use at any time during the five years. Pregabalin use was associated with greater pain severity and interference and greater use of high-risk opioid doses (>90 oral morphine equivalents/day). Pregabalin use was not associated with changes in mental health symptoms, ambulance or emergency department attendance in the fixed or random effects models. Conclusions: Pregabalin use was common, but for most people use was not associated with clinically meaningful improvements in pain or functioning.",
keywords = "cohort, gabapentinoids, opioid, pain, pharmacoepidemiology, pregabalin",
author = "Suzanne Nielsen and Natasa Gisev and Janni Leung and Philip Clare and Raimondo Bruno and Nicholas Lintzeris and Briony Larance and Fiona Blyth and Wayne Hall and Milton Cohen and Louisa Degenhardt and Michael Farrell and Gabrielle Campbell",
note = "Funding Information: The POINT study received funding from the Australian National Health and Medical Research Council (NHMRC, #1022522 and #1100822). S.N., L.D. and G.C. are supported by NHMRC research fellowships (#1163961, #1135991, #1119992). L.D. receives support through a National Institute of Health (NIH) National Institute on Drug Abuse (NIDA) grant (R01DA1104470). N.G. is supported by a UNSW Scientia Fellowship. The National Drug and Alcohol Research Centre, UNSW Sydney, is supported by funding from the Australian Government Department of Health under the Drug and Alcohol Program. Funding bodies had no role in study design, data analysis, data interpretation, data collection or writing of the article. Funding Information: The POINT study received funding from the Australian National Health and Medical Research Council (NHMRC, #1022522 and #1100822). S.N., L.D. and G.C. are supported by NHMRC research fellowships (#1163961, #1135991, #1119992). L.D. receives support through a National Institute of Health (NIH) National Institute on Drug Abuse (NIDA) grant (R01DA1104470). N.G. is supported by a UNSW Scientia Fellowship. The National Drug and Alcohol Research Centre, UNSW Sydney, is supported by funding from the Australian Government Department of Health under the Drug and Alcohol Program. Funding bodies had no role in study design, data analysis, data interpretation, data collection or writing of the article. Publisher Copyright: {\textcopyright} 2020 British Pharmacological Society. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = aug,
doi = "10.1111/bcp.14715",
language = "English",
volume = "87",
pages = "3092--3104",
journal = "British Journal of Clinical Pharmacology",
issn = "0306-5251",
publisher = "Wiley-Blackwell",
number = "8",
}