Klinische bewertung potentieller einsatzbereiche von rekombinantem faktor VIIa bei internistischen und pädiatrischen erkrankungen: Empfehlungen einer expertensruppe

Translated title of the contribution: Clinical assessment of potential fields of application of recombinant factor VIIa in internal and pediatric diseases. Recommendations of an expert group

Carl Erik Dempfle, Dietrich Gulba, Carl M. Kirchmaier, Robert Klamroth, Wolfgang Korte, Reinhard Lorenz, Markus Peck-Radosavljevic, Alex Veldman, Rainer B. Zotz

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Recombinant factor VIIa (rFVIIa) is increasingly used outside the labeled indications for treatment of life-threatening bleeding episodes after failure of the respective standard therapy. An interdisciplinary group of experts summarizes the state of knowledge of the use of rFVIIa in gastroenterology and hepatology, thrombocytopenia and -pathia, coagulation factor deficiencies, von Willebrand's disease, periinterventional bleeding without specific bleeding diathesis, drug-induced bleeding, disseminated intravascular coagulation, and neonatology. The most commonly used dose is 90 μg/kg body weight rFVIIa as bolus, if necessary followed by additional injections at intervals of 2-3 h. In factor VII deficiency lower dosages of 15-30 μg/kg body weight of rFVIIa are given every 4-6 h, whereas higher doses of 150-200 μg/kg body weight are used in neonates.

Translated title of the contributionClinical assessment of potential fields of application of recombinant factor VIIa in internal and pediatric diseases. Recommendations of an expert group
Original languageGerman
Pages (from-to)70-81
Number of pages12
JournalMedizinische Klinik
Volume102
Issue number1
DOIs
Publication statusPublished - Jan 2007
Externally publishedYes

Keywords

  • Bleeding
  • Coagulation disorder
  • Hemostasis
  • Recombinant factor VIIa

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