Clinical aspects of incorporating cord clamping into stabilisation of preterm infants

Ronny Knol, Emma Brouwer, Alex S.N. Vernooij, Frans J.C.M. Klumper, Philip Dekoninck, Stuart B. Hooper, Arjan B. Te Pas

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)


Fetal to neonatal transition is characterised by major pulmonary and haemodynamic changes occurring in a short period of time. In the international neonatal resuscitation guidelines, comprehensive recommendations are available on supporting pulmonary transition and delaying clamping of the cord in preterm infants. Recent experimental studies demonstrated that the pulmonary and haemodynamic transition are intimately linked, could influence each other and that the timing of umbilical cord clamping should be incorporated into the respiratory stabilisation. We reviewed the current knowledge on how to incorporate cord clamping into stabilisation of preterm infants and the physiological-based cord clamping (PBCC) approach, with the infant's transitional status as key determinant of timing of cord clamping. This approach could result in optimal timing of cord clamping and has the potential to reduce major morbidities and mortality in preterm infants.

Original languageEnglish
Pages (from-to)F493-F497
Number of pages5
JournalArchives of Disease in Childhood: Fetal and Neonatal Edition
Issue number5
Publication statusPublished - 1 Sep 2018


  • neonatology
  • physiology
  • resuscitation

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