Clinical applications and limitations of current ovarian stem cell research: A review

Karla J. Hutt, David F. Albertini

Research output: Contribution to journalReview ArticleResearchpeer-review

12 Citations (Scopus)

Abstract

The publication of a report in Nature in 2004 by the Tilly group suggesting that mouse ovaries are capable of generating oocytes de novo post-natally, has sparked interest in a problem long thought to have been resolved from classical studies in a variety of mammalian species. Within a nearly two year time period, laboratories around the world have taken up the challenge to dogma raised by this initial report, either to test this concept in an experimental basic science setting or give direction to clinical applications that could result, were the original premises of this work in the mouse valid for extrapolation to humans. This review provides a status report for this promising area of research, (1) to summarize recent findings in the literature with respect to the validity of the original hypothesis proffered by the Tilly group, and, (2) to gauge the potential utility of ovarian stem cells as a treatment for certain forms of human infertility.

Original languageEnglish
Article number6
JournalJournal of Experimental and Clinical Assisted Reproduction
Volume3
DOIs
Publication statusPublished - 27 Jul 2006

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