TY - JOUR
T1 - Clinical applications and limitations of current ovarian stem cell research
T2 - A review
AU - Hutt, Karla J.
AU - Albertini, David F.
PY - 2006/7/27
Y1 - 2006/7/27
N2 - The publication of a report in Nature in 2004 by the Tilly group suggesting that mouse ovaries are capable of generating oocytes de novo post-natally, has sparked interest in a problem long thought to have been resolved from classical studies in a variety of mammalian species. Within a nearly two year time period, laboratories around the world have taken up the challenge to dogma raised by this initial report, either to test this concept in an experimental basic science setting or give direction to clinical applications that could result, were the original premises of this work in the mouse valid for extrapolation to humans. This review provides a status report for this promising area of research, (1) to summarize recent findings in the literature with respect to the validity of the original hypothesis proffered by the Tilly group, and, (2) to gauge the potential utility of ovarian stem cells as a treatment for certain forms of human infertility.
AB - The publication of a report in Nature in 2004 by the Tilly group suggesting that mouse ovaries are capable of generating oocytes de novo post-natally, has sparked interest in a problem long thought to have been resolved from classical studies in a variety of mammalian species. Within a nearly two year time period, laboratories around the world have taken up the challenge to dogma raised by this initial report, either to test this concept in an experimental basic science setting or give direction to clinical applications that could result, were the original premises of this work in the mouse valid for extrapolation to humans. This review provides a status report for this promising area of research, (1) to summarize recent findings in the literature with respect to the validity of the original hypothesis proffered by the Tilly group, and, (2) to gauge the potential utility of ovarian stem cells as a treatment for certain forms of human infertility.
UR - http://www.scopus.com/inward/record.url?scp=33747866747&partnerID=8YFLogxK
U2 - 10.1186/1743-1050-3-6
DO - 10.1186/1743-1050-3-6
M3 - Review Article
AN - SCOPUS:33747866747
SN - 1743-1050
VL - 3
JO - Journal of Experimental and Clinical Assisted Reproduction
JF - Journal of Experimental and Clinical Assisted Reproduction
M1 - 6
ER -