TY - JOUR
T1 - Clinical and microbiological characteristics of eggerthella lenta bacteremia
AU - Gardiner, Bradley J
AU - Tai, Alex Y C
AU - Kotsanas, Despina
AU - Francis, Michelle J
AU - Roberts, Sally A
AU - Ballard, Susan Alicia
AU - Junckerstorff, Ralph K
AU - Korman, Tony
PY - 2015
Y1 - 2015
N2 - Eggerthella lenta is an emerging pathogen that has been underrecognized due to historical difficulties with phenotypic identification. Until now, its pathogenicity, antimicrobial susceptibility profile, and optimal treatment have been poorly characterized. In this article, we report the largest cohort of patients with E. lenta bacteremia to date and describe in detail their clinical features, microbiologic characteristics, treatment, and outcomes. We identified 33 patients; the median age was 68 years, and there was no gender predominance. Twenty-seven patients (82 ) had serious intra-abdominal pathology, often requiring a medical procedure. Of those who received antibiotics (28/33, 85 ), the median duration of treatment was 21.5 days. Mortality from all causes was 6 at 7 days, 12 at 30 days, and 33 at 1 year. Of 26 isolates available for further testing, all were identified as E. lenta by both commercially available matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems, and none were found to harbor a vanA or vanB gene. Of 23 isolates which underwent susceptibility testing, all were susceptible to amoxicillin-clavulanate, cefoxitin, metronidazole, piperacillin-tazobactam, ertapenem, and meropenem, 91 were susceptible to clindamycin, 74 were susceptible to moxifloxacin, and 39 were susceptible to penicillin. ? 2015, American Society for Microbiology. All Rights Reserved.
AB - Eggerthella lenta is an emerging pathogen that has been underrecognized due to historical difficulties with phenotypic identification. Until now, its pathogenicity, antimicrobial susceptibility profile, and optimal treatment have been poorly characterized. In this article, we report the largest cohort of patients with E. lenta bacteremia to date and describe in detail their clinical features, microbiologic characteristics, treatment, and outcomes. We identified 33 patients; the median age was 68 years, and there was no gender predominance. Twenty-seven patients (82 ) had serious intra-abdominal pathology, often requiring a medical procedure. Of those who received antibiotics (28/33, 85 ), the median duration of treatment was 21.5 days. Mortality from all causes was 6 at 7 days, 12 at 30 days, and 33 at 1 year. Of 26 isolates available for further testing, all were identified as E. lenta by both commercially available matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) systems, and none were found to harbor a vanA or vanB gene. Of 23 isolates which underwent susceptibility testing, all were susceptible to amoxicillin-clavulanate, cefoxitin, metronidazole, piperacillin-tazobactam, ertapenem, and meropenem, 91 were susceptible to clindamycin, 74 were susceptible to moxifloxacin, and 39 were susceptible to penicillin. ? 2015, American Society for Microbiology. All Rights Reserved.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298500/pdf/zjm626.pdf
U2 - 10.1128/JCM.02926-14
DO - 10.1128/JCM.02926-14
M3 - Article
SN - 0095-1137
VL - 53
SP - 626
EP - 635
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 2
ER -