Clinical and functional differences between early-onset and late-onset adult asthma: A population-based Tasmanian Longitudinal Health Study

Daniel J Tan, Eugene H Walters, Jennifer L. Perret, John A. Burgess, David P. Johns, Adrian J. Lowe, Caroline J. Lodge, Panteha Hayati Rezvan, Julie A Simpson, Stephen Morrison, Bruce R. Thompson, Paul S Thomas, Iain Feather, Graham G. Giles, John L. Hopper, Michael J. Abramson, Melanie C. Matheson, Shyamali C. Dharmage

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Background: Differences between early-onset and late-onset adult asthma have not been comprehensively described using prospective data. Aims To characterise the differences between early-onset and late-onset asthma in a longitudinal cohort study. 

Methods: The Tasmanian Longitudinal Health Study (TAHS) is a population-based cohort. Respiratory histories and spirometry were first performed in 1968 when participants were aged 7 (n=8583). The cohort was traced and resurveyed from 2002 to 2005 (n=5729 responses) and a sample, enriched for asthma and bronchitis participated in a clinical study when aged 44 (n=1389). 

Results: Of the entire TAHS cohort, 7.7% (95% CI 6.6% to 9.0%) had early-onset and 7.8% (95% CI 6.4% to 9.4%) late-onset asthma. Atopy and family history were more common in early-onset asthma while female gender, current smoking and low socioeconomic status were more common in late-onset asthma. The impact on lung function of early-onset asthma was significantly greater than for late-onset asthma (mean difference prebronchodilator (BD) FEV1/FVC -2.8% predicted (-5.3 to -0.3); post-BD FEV1FVC -2.6% predicted (-5.0 to -0.1)). However, asthma severity and asthma score did not significantly differ between groups. An interaction between asthma and smoking was identified and found to be associated with greater fixed airflow obstruction in adults with late-onset asthma. This interaction was not evident in adults with early-onset disease. 

Conclusions: Early-onset and late-onset adult asthma are equally prevalent in the middle-aged population. Major phenotypic differences occur with asthma age-ofonset; while both share similar clinical manifestations, the impact on adult lung function of early-onset asthma is greater than for late-onset asthma.

Original languageEnglish
Pages (from-to)981-987
Number of pages8
Issue number11
Publication statusPublished - Nov 2016

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