Click-engineered, bioresponsive, drug-loaded PEG spheres

Heng Pho Yap; Angus P R Johnston; Georgina Kate Such; Yan Yan; Frank Caruso

doi:10.1002/adma.200900421

Click-engineered, bioresponsive, drug-loaded PEG spheres

Heng Pho Yap, Angus P R Johnston, Georgina Kate Such, Yan Yan, Frank Caruso

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

A click-chemistry approach to synthesize bioresponsive poly(ethylene glycol acrylate) particles is described. The particles are loaded with a model anticancer drug (doxorubicin, DOX), and undergo simultaneous particle deconstruction and DOX release upon specific activation by the simulated environment of the cellular cytoplasm.

Original language	English
Pages (from-to)	4348-4352
Number of pages	5
Journal	Advanced Materials
Volume	21
Issue number	43
DOIs	https://doi.org/10.1002/adma.200900421
Publication status	Published - 20 Nov 2009
Externally published	Yes

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10.1002/adma.200900421

Link to publication in Scopus

Cite this

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title = "Click-engineered, bioresponsive, drug-loaded PEG spheres",

abstract = "A click-chemistry approach to synthesize bioresponsive poly(ethylene glycol acrylate) particles is described. The particles are loaded with a model anticancer drug (doxorubicin, DOX), and undergo simultaneous particle deconstruction and DOX release upon specific activation by the simulated environment of the cellular cytoplasm.",

author = "Yap, {Heng Pho} and Johnston, {Angus P R} and Such, {Georgina Kate} and Yan Yan and Frank Caruso",

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AU - Johnston, Angus P R

AU - Such, Georgina Kate

AU - Yan, Yan

AU - Caruso, Frank

PY - 2009/11/20

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AB - A click-chemistry approach to synthesize bioresponsive poly(ethylene glycol acrylate) particles is described. The particles are loaded with a model anticancer drug (doxorubicin, DOX), and undergo simultaneous particle deconstruction and DOX release upon specific activation by the simulated environment of the cellular cytoplasm.

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