Claustral afferents of superior parietal areas PEc and PE in the macaque

Michela Gamberini, Lauretta Passarelli, Sofia Bakola, Daniele Impieri, Patrizia Fattori, Marcello G. P. Rosa, Claudio Galletti

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The exposed surface of the primate superior parietal cortex includes two cytoarchitectonically defined areas, the PEc and PE. In the present study we describe the distribution of neurons projecting from the claustrum to these areas. Retrograde neuronal tracers were injected by direct visualization of regions of interest, and the location of injection sites was reconstructed relative to cytoarchitectural borders. For comparison, the patterns of claustral label that resulted from injections involving neighboring cytoarchitectonic areas were analyzed. We found that the claustral territories sending projections to areas PE and PEc partially overlapped zones previously shown to form projections to the posterior parietal, somatosensory, visual, and motor cortex. The projection zones to the PE and PEc overlapped extensively, and consisted of multiple patches separated by label-free zones. Most of the labeled neurons were located in the posterior–ventral part of the claustrum. Area PE received additional inputs from a posterior–dorsal part of the claustrum, which has been previously reported to project to the somatosensory cortex, while the PEc receives additional input from an anterior–ventral region of the claustrum, which has been reported to project to the visual association cortex. These observations reflect the known functional properties of the PE and PEc, with the former containing neurons that are predominantly involved in somatosensory processing, and the latter including both somatosensory and visual neurons. The present results suggest that the claustrum projections may help coordinate the activity of an extensive neural circuit involved in sensory and motor processing for movement execution.
Original languageEnglish
Pages (from-to)1475-1488
Number of pages14
JournalJournal of Comparative Neurology
Volume525
Issue number6
DOIs
Publication statusPublished - 15 Apr 2017

Cite this

Gamberini, Michela ; Passarelli, Lauretta ; Bakola, Sofia ; Impieri, Daniele ; Fattori, Patrizia ; Rosa, Marcello G. P. ; Galletti, Claudio. / Claustral afferents of superior parietal areas PEc and PE in the macaque. In: Journal of Comparative Neurology. 2017 ; Vol. 525, No. 6. pp. 1475-1488.
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abstract = "The exposed surface of the primate superior parietal cortex includes two cytoarchitectonically defined areas, the PEc and PE. In the present study we describe the distribution of neurons projecting from the claustrum to these areas. Retrograde neuronal tracers were injected by direct visualization of regions of interest, and the location of injection sites was reconstructed relative to cytoarchitectural borders. For comparison, the patterns of claustral label that resulted from injections involving neighboring cytoarchitectonic areas were analyzed. We found that the claustral territories sending projections to areas PE and PEc partially overlapped zones previously shown to form projections to the posterior parietal, somatosensory, visual, and motor cortex. The projection zones to the PE and PEc overlapped extensively, and consisted of multiple patches separated by label-free zones. Most of the labeled neurons were located in the posterior–ventral part of the claustrum. Area PE received additional inputs from a posterior–dorsal part of the claustrum, which has been previously reported to project to the somatosensory cortex, while the PEc receives additional input from an anterior–ventral region of the claustrum, which has been reported to project to the visual association cortex. These observations reflect the known functional properties of the PE and PEc, with the former containing neurons that are predominantly involved in somatosensory processing, and the latter including both somatosensory and visual neurons. The present results suggest that the claustrum projections may help coordinate the activity of an extensive neural circuit involved in sensory and motor processing for movement execution.",
author = "Michela Gamberini and Lauretta Passarelli and Sofia Bakola and Daniele Impieri and Patrizia Fattori and Rosa, {Marcello G. P.} and Claudio Galletti",
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Gamberini, M, Passarelli, L, Bakola, S, Impieri, D, Fattori, P, Rosa, MGP & Galletti, C 2017, 'Claustral afferents of superior parietal areas PEc and PE in the macaque' Journal of Comparative Neurology, vol. 525, no. 6, pp. 1475-1488. https://doi.org/10.1002/cne.24052

Claustral afferents of superior parietal areas PEc and PE in the macaque. / Gamberini, Michela; Passarelli, Lauretta; Bakola, Sofia; Impieri, Daniele; Fattori, Patrizia; Rosa, Marcello G. P.; Galletti, Claudio.

In: Journal of Comparative Neurology, Vol. 525, No. 6, 15.04.2017, p. 1475-1488.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Claustral afferents of superior parietal areas PEc and PE in the macaque

AU - Gamberini, Michela

AU - Passarelli, Lauretta

AU - Bakola, Sofia

AU - Impieri, Daniele

AU - Fattori, Patrizia

AU - Rosa, Marcello G. P.

AU - Galletti, Claudio

PY - 2017/4/15

Y1 - 2017/4/15

N2 - The exposed surface of the primate superior parietal cortex includes two cytoarchitectonically defined areas, the PEc and PE. In the present study we describe the distribution of neurons projecting from the claustrum to these areas. Retrograde neuronal tracers were injected by direct visualization of regions of interest, and the location of injection sites was reconstructed relative to cytoarchitectural borders. For comparison, the patterns of claustral label that resulted from injections involving neighboring cytoarchitectonic areas were analyzed. We found that the claustral territories sending projections to areas PE and PEc partially overlapped zones previously shown to form projections to the posterior parietal, somatosensory, visual, and motor cortex. The projection zones to the PE and PEc overlapped extensively, and consisted of multiple patches separated by label-free zones. Most of the labeled neurons were located in the posterior–ventral part of the claustrum. Area PE received additional inputs from a posterior–dorsal part of the claustrum, which has been previously reported to project to the somatosensory cortex, while the PEc receives additional input from an anterior–ventral region of the claustrum, which has been reported to project to the visual association cortex. These observations reflect the known functional properties of the PE and PEc, with the former containing neurons that are predominantly involved in somatosensory processing, and the latter including both somatosensory and visual neurons. The present results suggest that the claustrum projections may help coordinate the activity of an extensive neural circuit involved in sensory and motor processing for movement execution.

AB - The exposed surface of the primate superior parietal cortex includes two cytoarchitectonically defined areas, the PEc and PE. In the present study we describe the distribution of neurons projecting from the claustrum to these areas. Retrograde neuronal tracers were injected by direct visualization of regions of interest, and the location of injection sites was reconstructed relative to cytoarchitectural borders. For comparison, the patterns of claustral label that resulted from injections involving neighboring cytoarchitectonic areas were analyzed. We found that the claustral territories sending projections to areas PE and PEc partially overlapped zones previously shown to form projections to the posterior parietal, somatosensory, visual, and motor cortex. The projection zones to the PE and PEc overlapped extensively, and consisted of multiple patches separated by label-free zones. Most of the labeled neurons were located in the posterior–ventral part of the claustrum. Area PE received additional inputs from a posterior–dorsal part of the claustrum, which has been previously reported to project to the somatosensory cortex, while the PEc receives additional input from an anterior–ventral region of the claustrum, which has been reported to project to the visual association cortex. These observations reflect the known functional properties of the PE and PEc, with the former containing neurons that are predominantly involved in somatosensory processing, and the latter including both somatosensory and visual neurons. The present results suggest that the claustrum projections may help coordinate the activity of an extensive neural circuit involved in sensory and motor processing for movement execution.

UR - http://www.ncbi.nlm.nih.gov/pubmed/27243601

U2 - 10.1002/cne.24052

DO - 10.1002/cne.24052

M3 - Article

VL - 525

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EP - 1488

JO - Journal of Comparative Neurology

JF - Journal of Comparative Neurology

SN - 0021-9967

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ER -