Classification of aggressive and classic mantle cell lymphomas using synchrotron Fourier Transform Infrared microspectroscopy

Magdalena Kolodziej, Dorota Jesionek-Kupnicka, Marcin Braun, Vitaliy Atamanyuk, Sylwia Sloniec, Jozef Cebulski, Marian Cholewa, Janusz Kopczynski, Philip Heraud, Mark J. Tobin, Jitraporn Vongsvivut, Izabela Zawlik

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Mantle cell lymphoma (MCL) is regarded as an incurable neoplasm, even to the novel drug strategies. It is known MCL has two morphological variants- classic and aggressive. Aggressive MCL is characterized by a higher mitotic index and proliferation rate, and poor overall survival in comparison to classic subtype. The insight into the detailed biochemical composition of MCL is crucial in the further development of diagnostic and treatment guidelines for MCL patients; therefore Synchrotron radiation Fourier Transform Infrared (S-FTIR) microspectroscopy combined with Principal Component Analysis (PCA) was used. The major spectral differences were observed in proteins and nucleic acids content, revealing a classification scheme of classic and aggressive MCLs. The results obtained suggest that FTIR microspectroscopy has reflected the histopathological discrimination of both MCL subtypes.

Original languageEnglish
Article number12857
Number of pages8
JournalScientific Reports
Volume9
Issue number1
DOIs
Publication statusPublished - 6 Sep 2019

Keywords

  • b-cell lymphoma
  • infrared spectroscopy

Cite this

Kolodziej, M., Jesionek-Kupnicka, D., Braun, M., Atamanyuk, V., Sloniec, S., Cebulski, J., ... Zawlik, I. (2019). Classification of aggressive and classic mantle cell lymphomas using synchrotron Fourier Transform Infrared microspectroscopy. Scientific Reports, 9(1), [12857]. https://doi.org/10.1038/s41598-019-49326-3
Kolodziej, Magdalena ; Jesionek-Kupnicka, Dorota ; Braun, Marcin ; Atamanyuk, Vitaliy ; Sloniec, Sylwia ; Cebulski, Jozef ; Cholewa, Marian ; Kopczynski, Janusz ; Heraud, Philip ; Tobin, Mark J. ; Vongsvivut, Jitraporn ; Zawlik, Izabela. / Classification of aggressive and classic mantle cell lymphomas using synchrotron Fourier Transform Infrared microspectroscopy. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
@article{d58282aefd8148649aa2c01dae03031c,
title = "Classification of aggressive and classic mantle cell lymphomas using synchrotron Fourier Transform Infrared microspectroscopy",
abstract = "Mantle cell lymphoma (MCL) is regarded as an incurable neoplasm, even to the novel drug strategies. It is known MCL has two morphological variants- classic and aggressive. Aggressive MCL is characterized by a higher mitotic index and proliferation rate, and poor overall survival in comparison to classic subtype. The insight into the detailed biochemical composition of MCL is crucial in the further development of diagnostic and treatment guidelines for MCL patients; therefore Synchrotron radiation Fourier Transform Infrared (S-FTIR) microspectroscopy combined with Principal Component Analysis (PCA) was used. The major spectral differences were observed in proteins and nucleic acids content, revealing a classification scheme of classic and aggressive MCLs. The results obtained suggest that FTIR microspectroscopy has reflected the histopathological discrimination of both MCL subtypes.",
keywords = "b-cell lymphoma, infrared spectroscopy",
author = "Magdalena Kolodziej and Dorota Jesionek-Kupnicka and Marcin Braun and Vitaliy Atamanyuk and Sylwia Sloniec and Jozef Cebulski and Marian Cholewa and Janusz Kopczynski and Philip Heraud and Tobin, {Mark J.} and Jitraporn Vongsvivut and Izabela Zawlik",
year = "2019",
month = "9",
day = "6",
doi = "10.1038/s41598-019-49326-3",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

Kolodziej, M, Jesionek-Kupnicka, D, Braun, M, Atamanyuk, V, Sloniec, S, Cebulski, J, Cholewa, M, Kopczynski, J, Heraud, P, Tobin, MJ, Vongsvivut, J & Zawlik, I 2019, 'Classification of aggressive and classic mantle cell lymphomas using synchrotron Fourier Transform Infrared microspectroscopy', Scientific Reports, vol. 9, no. 1, 12857. https://doi.org/10.1038/s41598-019-49326-3

Classification of aggressive and classic mantle cell lymphomas using synchrotron Fourier Transform Infrared microspectroscopy. / Kolodziej, Magdalena; Jesionek-Kupnicka, Dorota; Braun, Marcin; Atamanyuk, Vitaliy; Sloniec, Sylwia; Cebulski, Jozef; Cholewa, Marian; Kopczynski, Janusz; Heraud, Philip; Tobin, Mark J.; Vongsvivut, Jitraporn; Zawlik, Izabela.

In: Scientific Reports, Vol. 9, No. 1, 12857, 06.09.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Classification of aggressive and classic mantle cell lymphomas using synchrotron Fourier Transform Infrared microspectroscopy

AU - Kolodziej, Magdalena

AU - Jesionek-Kupnicka, Dorota

AU - Braun, Marcin

AU - Atamanyuk, Vitaliy

AU - Sloniec, Sylwia

AU - Cebulski, Jozef

AU - Cholewa, Marian

AU - Kopczynski, Janusz

AU - Heraud, Philip

AU - Tobin, Mark J.

AU - Vongsvivut, Jitraporn

AU - Zawlik, Izabela

PY - 2019/9/6

Y1 - 2019/9/6

N2 - Mantle cell lymphoma (MCL) is regarded as an incurable neoplasm, even to the novel drug strategies. It is known MCL has two morphological variants- classic and aggressive. Aggressive MCL is characterized by a higher mitotic index and proliferation rate, and poor overall survival in comparison to classic subtype. The insight into the detailed biochemical composition of MCL is crucial in the further development of diagnostic and treatment guidelines for MCL patients; therefore Synchrotron radiation Fourier Transform Infrared (S-FTIR) microspectroscopy combined with Principal Component Analysis (PCA) was used. The major spectral differences were observed in proteins and nucleic acids content, revealing a classification scheme of classic and aggressive MCLs. The results obtained suggest that FTIR microspectroscopy has reflected the histopathological discrimination of both MCL subtypes.

AB - Mantle cell lymphoma (MCL) is regarded as an incurable neoplasm, even to the novel drug strategies. It is known MCL has two morphological variants- classic and aggressive. Aggressive MCL is characterized by a higher mitotic index and proliferation rate, and poor overall survival in comparison to classic subtype. The insight into the detailed biochemical composition of MCL is crucial in the further development of diagnostic and treatment guidelines for MCL patients; therefore Synchrotron radiation Fourier Transform Infrared (S-FTIR) microspectroscopy combined with Principal Component Analysis (PCA) was used. The major spectral differences were observed in proteins and nucleic acids content, revealing a classification scheme of classic and aggressive MCLs. The results obtained suggest that FTIR microspectroscopy has reflected the histopathological discrimination of both MCL subtypes.

KW - b-cell lymphoma

KW - infrared spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=85071896466&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-49326-3

DO - 10.1038/s41598-019-49326-3

M3 - Article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 12857

ER -