Class-Switch Recombination Occurs Infrequently in Germinal Centers

Jonathan A. Roco, Luka Mesin, Sebastian C. Binder, Christian Nefzger, Paula Gonzalez-Figueroa, Pablo F. Canete, Julia Ellyard, Qian Shen, Philippe A. Robert, Jean Cappello, Harpreet Vohra, Yang Zhang, Carla R. Nowosad, Arien Schiepers, Lynn M. Corcoran, Kai Michael Toellner, Jose M. Polo, Michael Meyer-Hermann, Gabriel D. Victora, Carola G. Vinuesa

Research output: Contribution to journalArticleResearchpeer-review

112 Citations (Scopus)


Germinal centers (GCs) have long been considered sites in which Ig class-switch recombination (CSR) is favored. Roco et al. show that CSR occurs during the initial T cell:B cell interaction prior to GC formation and rapidly declines as B cells differentiate into GC cells and somatic hypermutation commences.

Original languageEnglish
Pages (from-to)337-350
Number of pages14
Issue number2
Publication statusPublished - 20 Aug 2019

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