Class-Switch Recombination Occurs Infrequently in Germinal Centers

Jonathan A. Roco, Luka Mesin, Sebastian C. Binder, Christian Nefzger, Paula Gonzalez-Figueroa, Pablo F. Canete, Julia Ellyard, Qian Shen, Philippe A. Robert, Jean Cappello, Harpreet Vohra, Yang Zhang, Carla R. Nowosad, Arien Schiepers, Lynn M. Corcoran, Kai Michael Toellner, Jose M. Polo, Michael Meyer-Hermann, Gabriel D. Victora, Carola G. Vinuesa

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16 Citations (Scopus)

Abstract

Germinal centers (GCs) have long been considered sites in which Ig class-switch recombination (CSR) is favored. Roco et al. show that CSR occurs during the initial T cell:B cell interaction prior to GC formation and rapidly declines as B cells differentiate into GC cells and somatic hypermutation commences.

Original languageEnglish
Pages (from-to)337-350
Number of pages14
JournalImmunity
Volume51
Issue number2
DOIs
Publication statusPublished - 20 Aug 2019

Cite this

Roco, J. A., Mesin, L., Binder, S. C., Nefzger, C., Gonzalez-Figueroa, P., Canete, P. F., Ellyard, J., Shen, Q., Robert, P. A., Cappello, J., Vohra, H., Zhang, Y., Nowosad, C. R., Schiepers, A., Corcoran, L. M., Toellner, K. M., Polo, J. M., Meyer-Hermann, M., Victora, G. D., & Vinuesa, C. G. (2019). Class-Switch Recombination Occurs Infrequently in Germinal Centers. Immunity, 51(2), 337-350. https://doi.org/10.1016/j.immuni.2019.07.001