Citrobacter rodentium infection model for the analysis of bacterial pathogenesis and mucosal immunology

Catherine L. Kennedy; Elizabeth L. Hartland

doi:10.1007/978-1-4939-7568-6_7

Citrobacter rodentium infection model for the analysis of bacterial pathogenesis and mucosal immunology

Catherine L. Kennedy, Elizabeth L. Hartland

Hudson Institute - Department of Molecular and Translational Science

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

7 Citations (Scopus)

Abstract

Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases. As such, the C. rodentium infection model has become a key tool in investigations of many aspects of mucosal immunology.

Original language	English
Title of host publication	Methods in Molecular Biology
Editors	Brendan J. Jenkins
Place of Publication	New York, NY
Publisher	Humana Press
Chapter	7
Pages	77-89
Number of pages	13
ISBN (Electronic)	9781493975686
ISBN (Print)	9781493975679
DOIs	https://doi.org/10.1007/978-1-4939-7568-6_7
Publication status	Published - 2018

Publication series

Name	Methods in Molecular Biology
Publisher	Humana Press, Inc.
Volume	1725
ISSN (Print)	1064-3745
ISSN (Electronic)	1940-6029

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bacterial culture
Bacterial infection
Citrobacter rodentium
Colitis
Immune cell analysis
Mucosal immunity

Access to Document

10.1007/978-1-4939-7568-6_7

Cite this

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abstract = "Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases. As such, the C. rodentium infection model has become a key tool in investigations of many aspects of mucosal immunology.",

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Citrobacter rodentium infection model for the analysis of bacterial pathogenesis and mucosal immunology. / Kennedy, Catherine L.; Hartland, Elizabeth L.
Methods in Molecular Biology. ed. / Brendan J. Jenkins. New York, NY: Humana Press, 2018. p. 77-89 (Methods in Molecular Biology; Vol. 1725).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

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AU - Kennedy, Catherine L.

AU - Hartland, Elizabeth L.

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N2 - Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases. As such, the C. rodentium infection model has become a key tool in investigations of many aspects of mucosal immunology.

AB - Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases. As such, the C. rodentium infection model has become a key tool in investigations of many aspects of mucosal immunology.

KW - Bacterial culture

KW - Bacterial infection

KW - Citrobacter rodentium

KW - Colitis

KW - Immune cell analysis

KW - Mucosal immunity

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T3 - Methods in Molecular Biology

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PB - Humana Press

CY - New York, NY

ER -

Citrobacter rodentium infection model for the analysis of bacterial pathogenesis and mucosal immunology

Abstract

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UN SDGs

Keywords

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