Citrobacter rodentium infection model for the analysis of bacterial pathogenesis and mucosal immunology

Catherine L. Kennedy, Elizabeth L. Hartland

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

3 Citations (Scopus)

Abstract

Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases. As such, the C. rodentium infection model has become a key tool in investigations of many aspects of mucosal immunology.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
EditorsBrendan J. Jenkins
Place of PublicationNew York, NY
PublisherHumana Press
Chapter7
Pages77-89
Number of pages13
ISBN (Electronic)9781493975686
ISBN (Print)9781493975679
DOIs
Publication statusPublished - 2018

Publication series

NameMethods in Molecular Biology
PublisherHumana Press, Inc.
Volume1725
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Bacterial culture
  • Bacterial infection
  • Citrobacter rodentium
  • Colitis
  • Immune cell analysis
  • Mucosal immunity

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