Abstract
Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases. As such, the C. rodentium infection model has become a key tool in investigations of many aspects of mucosal immunology.
| Original language | English |
|---|---|
| Title of host publication | Methods in Molecular Biology |
| Editors | Brendan J. Jenkins |
| Place of Publication | New York, NY |
| Publisher | Humana Press |
| Chapter | 7 |
| Pages | 77-89 |
| Number of pages | 13 |
| ISBN (Electronic) | 9781493975686 |
| ISBN (Print) | 9781493975679 |
| DOIs | |
| Publication status | Published - 2018 |
Publication series
| Name | Methods in Molecular Biology |
|---|---|
| Publisher | Humana Press, Inc. |
| Volume | 1725 |
| ISSN (Print) | 1064-3745 |
| ISSN (Electronic) | 1940-6029 |
Keywords
- Bacterial culture
- Bacterial infection
- Citrobacter rodentium
- Colitis
- Immune cell analysis
- Mucosal immunity
Cite this
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Citrobacter rodentium infection model for the analysis of bacterial pathogenesis and mucosal immunology. / Kennedy, Catherine L.; Hartland, Elizabeth L.
Methods in Molecular Biology. ed. / Brendan J. Jenkins. New York, NY : Humana Press, 2018. p. 77-89 (Methods in Molecular Biology; Vol. 1725).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
TY - CHAP
T1 - Citrobacter rodentium infection model for the analysis of bacterial pathogenesis and mucosal immunology
AU - Kennedy, Catherine L.
AU - Hartland, Elizabeth L.
PY - 2018
Y1 - 2018
N2 - Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases. As such, the C. rodentium infection model has become a key tool in investigations of many aspects of mucosal immunology.
AB - Citrobacter rodentium is a mouse restricted pathogen that was originally isolated from laboratory mouse colonies and causes transmissible colonic hyperplasia, characterized by thickening of the colon and inflammation. As a natural pathogen of mice, the infection model has proven critical to the development of our understanding of the pathogenesis of enteric disease and the mucosal immune response. In addition to this, some features of disease such as dysbiosis, inflammation, and wound healing replicate features of human inflammatory bowel diseases. As such, the C. rodentium infection model has become a key tool in investigations of many aspects of mucosal immunology.
KW - Bacterial culture
KW - Bacterial infection
KW - Citrobacter rodentium
KW - Colitis
KW - Immune cell analysis
KW - Mucosal immunity
UR - http://www.scopus.com/inward/record.url?scp=85040688900&partnerID=8YFLogxK
U2 - 10.1007/978-1-4939-7568-6_7
DO - 10.1007/978-1-4939-7568-6_7
M3 - Chapter (Book)
SN - 9781493975679
T3 - Methods in Molecular Biology
SP - 77
EP - 89
BT - Methods in Molecular Biology
A2 - Jenkins, Brendan J.
PB - Humana Press
CY - New York, NY
ER -