TY - JOUR
T1 - Cisplatin versus carboplatin
T2 - Comparative review of therapeutic management in solid malignancies
AU - Ho, Gwo Yaw
AU - Woodward, Natasha
AU - Coward, Jermaine I.G.
PY - 2016/6/1
Y1 - 2016/6/1
N2 - The platinum analogues, cisplatin and carboplatin, are among the most widely used chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity in numerous malignancies including gynaecological cancers, germ cell tumours, head and neck cancer, thoracic cancers and bladder cancer. Although the final mechanism of inducing tumour cell apoptosis is similar for both compounds, cisplatin has been shown to be more effective in treating specific tumour types. Whilst more favourable toxicity profiles are often associated with carboplatin, this can frequently translate to inferior response in certain malignancies. This review succinctly collates the evidence for the preferential use of these platinum analogues in particular settings in addition to the long-standing dilemma surrounding the paucity of biomarkers predicting response to these agents.
AB - The platinum analogues, cisplatin and carboplatin, are among the most widely used chemotherapeutic agents in oncology. Both agents have a broad spectrum of clinical activity in numerous malignancies including gynaecological cancers, germ cell tumours, head and neck cancer, thoracic cancers and bladder cancer. Although the final mechanism of inducing tumour cell apoptosis is similar for both compounds, cisplatin has been shown to be more effective in treating specific tumour types. Whilst more favourable toxicity profiles are often associated with carboplatin, this can frequently translate to inferior response in certain malignancies. This review succinctly collates the evidence for the preferential use of these platinum analogues in particular settings in addition to the long-standing dilemma surrounding the paucity of biomarkers predicting response to these agents.
KW - Carboplatin
KW - Cisplatin
KW - Platinum resistance
KW - Platinum sensitivity
KW - Platinum-based chemotherapy
KW - Radio-sensitisation
UR - http://www.scopus.com/inward/record.url?scp=84963800478&partnerID=8YFLogxK
U2 - 10.1016/j.critrevonc.2016.03.014
DO - 10.1016/j.critrevonc.2016.03.014
M3 - Review Article
C2 - 27105947
AN - SCOPUS:84963800478
VL - 102
SP - 37
EP - 46
JO - Critical Reviews in Oncology/Hematology
JF - Critical Reviews in Oncology/Hematology
SN - 1040-8428
ER -