TY - JOUR
T1 - Cisplatin-based chemotherapy for ovarian germ cell malignancies
T2 - The Australian experience
AU - Segelov, Eva
AU - Campbell, Jenny
AU - Ng, Maria
AU - Tattersall, Martin
AU - Rome, Robert
AU - Free, Keith
AU - Hacker, Neville
AU - Friedlander, Michael L.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Purpose: This study was performed to evaluate the Australian experience with cisplatin-based treatment of ovarian germ cell tumors (OGCT) with respect to survival and toxicity of treatment. Patients and Methods: A retrospective review was undertaken based on a standardized questionnaire, which was sent to all major gynecologic oncology centers in Australia. Results: Data on 58 patients were obtained. Overall survival at 5 years for all patients was 87%. There was one death from disease among 14 patients with dysgerminoma, and four deaths from disease among 44 patients with nondysgerminomas. Cisplatin-based chemotherapy was associated with a low incidence of serious complications, with only one treatment-related death (from bleomycin-induced respiratory failure). Conclusion: Our large series demonstrates that cisplatin-based chemotherapy is highly effective for patients with OGCT. Although direct comparisons cannot be made, the survival of our patients with advanced tumors was comparable to that seen in male germ cell tumors, rather than inferior as is commonly believed. Future studies should aim to refine treatment to minimize toxicity, while further increasing curability.
AB - Purpose: This study was performed to evaluate the Australian experience with cisplatin-based treatment of ovarian germ cell tumors (OGCT) with respect to survival and toxicity of treatment. Patients and Methods: A retrospective review was undertaken based on a standardized questionnaire, which was sent to all major gynecologic oncology centers in Australia. Results: Data on 58 patients were obtained. Overall survival at 5 years for all patients was 87%. There was one death from disease among 14 patients with dysgerminoma, and four deaths from disease among 44 patients with nondysgerminomas. Cisplatin-based chemotherapy was associated with a low incidence of serious complications, with only one treatment-related death (from bleomycin-induced respiratory failure). Conclusion: Our large series demonstrates that cisplatin-based chemotherapy is highly effective for patients with OGCT. Although direct comparisons cannot be made, the survival of our patients with advanced tumors was comparable to that seen in male germ cell tumors, rather than inferior as is commonly believed. Future studies should aim to refine treatment to minimize toxicity, while further increasing curability.
UR - http://www.scopus.com/inward/record.url?scp=0027979181&partnerID=8YFLogxK
U2 - 10.1200/JCO.1994.12.2.378
DO - 10.1200/JCO.1994.12.2.378
M3 - Article
C2 - 8113845
AN - SCOPUS:0027979181
SN - 0732-183X
VL - 12
SP - 378
EP - 384
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 2
ER -