Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

M. Matejcic, F. Lesueur, C. Biessy, A. L. Renault, N. Mebirouk, S. Yammine, P. Keski-Rahkonen, K. Li, B. Hémon, E. Weiderpass, V. Rebours, M. C. Boutron-Ruault, F. Carbonnel, R. Kaaks, V. Katzke, T. Kuhn, H. Boeing, A. Trichopoulou, D. Palli, C. Agnoli & 21 others S. Panico, R. Tumino, C. Sacerdote, J. R. Quirós, E. J. Duell, M. Porta, M. J. Sánchez, M. D. Chirlaque, A. Barricarte, P. Amiano, W. Ye, P. H. Peeters, K. T. Khaw, A. Perez-Cornago, T. J. Key, H. B. Bueno-de-Mesquita, E. Riboli, P. Vineis, I. Romieu, M. J. Gunter, V. Chajès

Research output: Contribution to journalArticleResearchpeer-review

Abstract

There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3-T1[odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41–0.98; ptrend = 0.036), n-3 polyunsaturated α-linolenic acid (ORT3-T1 = 0.60; 95%CI = 0.39–0.92; ptrend = 0.02) and docosapentaenoic acid (ORT3-T1 = 0.52; 95%CI = 0.32–0.85; ptrend = 0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (ORT3-T1 = 3.00; 95%CI = 1.13–7.99; ptrend = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3-T1 = 0.37; 95%CI = 0.17–0.81; ptrend = 0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3-T1 = 3.40; 95%CI = 1.39–8.34; ptrend = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking.

Original languageEnglish
Pages (from-to)2437-2448
Number of pages12
JournalInternational Journal of Cancer
Volume143
Issue number10
DOIs
Publication statusPublished - 15 Nov 2018
Externally publishedYes

Keywords

  • biomarkers
  • fatty acids
  • pancreatic cancer
  • plasma phospholipids
  • tobacco smoking

Cite this

Matejcic, M. ; Lesueur, F. ; Biessy, C. ; Renault, A. L. ; Mebirouk, N. ; Yammine, S. ; Keski-Rahkonen, P. ; Li, K. ; Hémon, B. ; Weiderpass, E. ; Rebours, V. ; Boutron-Ruault, M. C. ; Carbonnel, F. ; Kaaks, R. ; Katzke, V. ; Kuhn, T. ; Boeing, H. ; Trichopoulou, A. ; Palli, D. ; Agnoli, C. ; Panico, S. ; Tumino, R. ; Sacerdote, C. ; Quirós, J. R. ; Duell, E. J. ; Porta, M. ; Sánchez, M. J. ; Chirlaque, M. D. ; Barricarte, A. ; Amiano, P. ; Ye, W. ; Peeters, P. H. ; Khaw, K. T. ; Perez-Cornago, A. ; Key, T. J. ; Bueno-de-Mesquita, H. B. ; Riboli, E. ; Vineis, P. ; Romieu, I. ; Gunter, M. J. ; Chajès, V. / Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort. In: International Journal of Cancer. 2018 ; Vol. 143, No. 10. pp. 2437-2448.
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title = "Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort",
abstract = "There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3-T1[odds ratio for highest versus lowest tertile] =0.63; 95{\%}CI[confidence interval] = 0.41–0.98; ptrend = 0.036), n-3 polyunsaturated α-linolenic acid (ORT3-T1 = 0.60; 95{\%}CI = 0.39–0.92; ptrend = 0.02) and docosapentaenoic acid (ORT3-T1 = 0.52; 95{\%}CI = 0.32–0.85; ptrend = 0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (ORT3-T1 = 3.00; 95{\%}CI = 1.13–7.99; ptrend = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3-T1 = 0.37; 95{\%}CI = 0.17–0.81; ptrend = 0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3-T1 = 3.40; 95{\%}CI = 1.39–8.34; ptrend = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking.",
keywords = "biomarkers, fatty acids, pancreatic cancer, plasma phospholipids, tobacco smoking",
author = "M. Matejcic and F. Lesueur and C. Biessy and Renault, {A. L.} and N. Mebirouk and S. Yammine and P. Keski-Rahkonen and K. Li and B. H{\'e}mon and E. Weiderpass and V. Rebours and Boutron-Ruault, {M. C.} and F. Carbonnel and R. Kaaks and V. Katzke and T. Kuhn and H. Boeing and A. Trichopoulou and D. Palli and C. Agnoli and S. Panico and R. Tumino and C. Sacerdote and Quir{\'o}s, {J. R.} and Duell, {E. J.} and M. Porta and S{\'a}nchez, {M. J.} and Chirlaque, {M. D.} and A. Barricarte and P. Amiano and W. Ye and Peeters, {P. H.} and Khaw, {K. T.} and A. Perez-Cornago and Key, {T. J.} and Bueno-de-Mesquita, {H. B.} and E. Riboli and P. Vineis and I. Romieu and Gunter, {M. J.} and V. Chaj{\`e}s",
year = "2018",
month = "11",
day = "15",
doi = "10.1002/ijc.31797",
language = "English",
volume = "143",
pages = "2437--2448",
journal = "International Journal of Cancer",
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Matejcic, M, Lesueur, F, Biessy, C, Renault, AL, Mebirouk, N, Yammine, S, Keski-Rahkonen, P, Li, K, Hémon, B, Weiderpass, E, Rebours, V, Boutron-Ruault, MC, Carbonnel, F, Kaaks, R, Katzke, V, Kuhn, T, Boeing, H, Trichopoulou, A, Palli, D, Agnoli, C, Panico, S, Tumino, R, Sacerdote, C, Quirós, JR, Duell, EJ, Porta, M, Sánchez, MJ, Chirlaque, MD, Barricarte, A, Amiano, P, Ye, W, Peeters, PH, Khaw, KT, Perez-Cornago, A, Key, TJ, Bueno-de-Mesquita, HB, Riboli, E, Vineis, P, Romieu, I, Gunter, MJ & Chajès, V 2018, 'Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort', International Journal of Cancer, vol. 143, no. 10, pp. 2437-2448. https://doi.org/10.1002/ijc.31797

Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort. / Matejcic, M.; Lesueur, F.; Biessy, C.; Renault, A. L.; Mebirouk, N.; Yammine, S.; Keski-Rahkonen, P.; Li, K.; Hémon, B.; Weiderpass, E.; Rebours, V.; Boutron-Ruault, M. C.; Carbonnel, F.; Kaaks, R.; Katzke, V.; Kuhn, T.; Boeing, H.; Trichopoulou, A.; Palli, D.; Agnoli, C.; Panico, S.; Tumino, R.; Sacerdote, C.; Quirós, J. R.; Duell, E. J.; Porta, M.; Sánchez, M. J.; Chirlaque, M. D.; Barricarte, A.; Amiano, P.; Ye, W.; Peeters, P. H.; Khaw, K. T.; Perez-Cornago, A.; Key, T. J.; Bueno-de-Mesquita, H. B.; Riboli, E.; Vineis, P.; Romieu, I.; Gunter, M. J.; Chajès, V.

In: International Journal of Cancer, Vol. 143, No. 10, 15.11.2018, p. 2437-2448.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

AU - Matejcic, M.

AU - Lesueur, F.

AU - Biessy, C.

AU - Renault, A. L.

AU - Mebirouk, N.

AU - Yammine, S.

AU - Keski-Rahkonen, P.

AU - Li, K.

AU - Hémon, B.

AU - Weiderpass, E.

AU - Rebours, V.

AU - Boutron-Ruault, M. C.

AU - Carbonnel, F.

AU - Kaaks, R.

AU - Katzke, V.

AU - Kuhn, T.

AU - Boeing, H.

AU - Trichopoulou, A.

AU - Palli, D.

AU - Agnoli, C.

AU - Panico, S.

AU - Tumino, R.

AU - Sacerdote, C.

AU - Quirós, J. R.

AU - Duell, E. J.

AU - Porta, M.

AU - Sánchez, M. J.

AU - Chirlaque, M. D.

AU - Barricarte, A.

AU - Amiano, P.

AU - Ye, W.

AU - Peeters, P. H.

AU - Khaw, K. T.

AU - Perez-Cornago, A.

AU - Key, T. J.

AU - Bueno-de-Mesquita, H. B.

AU - Riboli, E.

AU - Vineis, P.

AU - Romieu, I.

AU - Gunter, M. J.

AU - Chajès, V.

PY - 2018/11/15

Y1 - 2018/11/15

N2 - There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3-T1[odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41–0.98; ptrend = 0.036), n-3 polyunsaturated α-linolenic acid (ORT3-T1 = 0.60; 95%CI = 0.39–0.92; ptrend = 0.02) and docosapentaenoic acid (ORT3-T1 = 0.52; 95%CI = 0.32–0.85; ptrend = 0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (ORT3-T1 = 3.00; 95%CI = 1.13–7.99; ptrend = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3-T1 = 0.37; 95%CI = 0.17–0.81; ptrend = 0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3-T1 = 3.40; 95%CI = 1.39–8.34; ptrend = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking.

AB - There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3-T1[odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41–0.98; ptrend = 0.036), n-3 polyunsaturated α-linolenic acid (ORT3-T1 = 0.60; 95%CI = 0.39–0.92; ptrend = 0.02) and docosapentaenoic acid (ORT3-T1 = 0.52; 95%CI = 0.32–0.85; ptrend = 0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (ORT3-T1 = 3.00; 95%CI = 1.13–7.99; ptrend = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3-T1 = 0.37; 95%CI = 0.17–0.81; ptrend = 0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3-T1 = 3.40; 95%CI = 1.39–8.34; ptrend = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking.

KW - biomarkers

KW - fatty acids

KW - pancreatic cancer

KW - plasma phospholipids

KW - tobacco smoking

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U2 - 10.1002/ijc.31797

DO - 10.1002/ijc.31797

M3 - Article

VL - 143

SP - 2437

EP - 2448

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 10

ER -