Circulating interleukin-6 in relation to adiposity, insulin action and insulin secretion

Barbora Vozarova, Christian Weyer, Kristin Hanson, P Antonio Tataranni, Clifton Bogardus, Richard E Pratley

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Abstract

VOZAROVA, BARBORA, CHRISTIAN WEYER, KRISTIN HANSON, P. ANTONIO TATARANNI, CLIFTON BOGARDUS, AND RICHARD E. PRATLEY. Circulating interleukin-6 in relation to adiposity, insulin action, and insulin secretion. Obes Res. 2001;9:414?417. Objective: Plasma concentrations of interleukin-6 (IL-6), a proinflammatory cytokine produced and released in part by adipose tissue, are elevated in people with obesity and type 2 diabetes. Because recent studies suggest that markers of inflammation predict the development of type 2 diabetes, we examined whether circulating plasma IL-6 concentrations were related to direct measures of insulin resistance and insulin secretory dysfunction in Pima Indians, a population with high rates of obesity and type 2 diabetes. Research Methods and Procedures: Fasting plasma IL-6 concentrations (enzyme-linked immunosorbent assay), body composition (DXA), insulin action (M; hyperinsulinemic euglycemic clamp), and acute insulin secretory responses to glucose (25 g intravenous glucose tolerance test) were measured in 58 Pima Indians without diabetes (24 women, 34 men). Results: Fasting plasma IL-6 concentrations were positively correlated with percentage of body fat (r 5 0.26, p 5 0.049) and negatively correlated with M (r 5 20.28, p 5 0.031), but were not related to acute insulin response (r 5 0.13, p 5 0.339). After adjusting for percentage of body fat, plasma IL-6 was not related to M (partial r 5 20.23, p 5 0.089). Discussion: Fasting plasma IL-6 concentrations are positively related to adiposity and negatively related to insulin action in Pima Indians. The relationship between IL-6 and insulin action seems to be mediated through adiposity.
Original languageEnglish
Pages (from-to)414 - 417
Number of pages4
JournalObesity
Volume9
Issue number7
Publication statusPublished - 2001
Externally publishedYes

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