Abstract
VOZAROVA, BARBORA, CHRISTIAN WEYER, KRISTIN
HANSON, P. ANTONIO TATARANNI, CLIFTON
BOGARDUS, AND RICHARD E. PRATLEY. Circulating
interleukin-6 in relation to adiposity, insulin action, and
insulin secretion. Obes Res. 2001;9:414?417.
Objective: Plasma concentrations of interleukin-6 (IL-6), a
proinflammatory cytokine produced and released in part by
adipose tissue, are elevated in people with obesity and type
2 diabetes. Because recent studies suggest that markers of
inflammation predict the development of type 2 diabetes,
we examined whether circulating plasma IL-6 concentrations
were related to direct measures of insulin resistance
and insulin secretory dysfunction in Pima Indians, a population
with high rates of obesity and type 2 diabetes.
Research Methods and Procedures: Fasting plasma IL-6
concentrations (enzyme-linked immunosorbent assay),
body composition (DXA), insulin action (M; hyperinsulinemic
euglycemic clamp), and acute insulin secretory responses
to glucose (25 g intravenous glucose tolerance test)
were measured in 58 Pima Indians without diabetes (24
women, 34 men).
Results: Fasting plasma IL-6 concentrations were positively
correlated with percentage of body fat (r 5 0.26, p 5 0.049)
and negatively correlated with M (r 5 20.28, p 5 0.031),
but were not related to acute insulin response (r 5 0.13, p 5
0.339). After adjusting for percentage of body fat, plasma
IL-6 was not related to M (partial r 5 20.23, p 5 0.089).
Discussion: Fasting plasma IL-6 concentrations are positively
related to adiposity and negatively related to insulin
action in Pima Indians. The relationship between IL-6 and
insulin action seems to be mediated through adiposity.
| Original language | English |
|---|---|
| Pages (from-to) | 414 - 417 |
| Number of pages | 4 |
| Journal | Obesity |
| Volume | 9 |
| Issue number | 7 |
| Publication status | Published - 2001 |
| Externally published | Yes |
