Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy

Itaru Anraku, Reena Rajasuriar, Caroline A Dobbin, Richard Brown, Sharon R Lewin, Andreas Suhrbier

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients
Original languageEnglish
Article numbere45291
Number of pages4
JournalPLoS ONE
Volume7
Issue number9
DOIs
Publication statusPublished - 2012

Cite this

Anraku, Itaru ; Rajasuriar, Reena ; Dobbin, Caroline A ; Brown, Richard ; Lewin, Sharon R ; Suhrbier, Andreas. / Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy. In: PLoS ONE. 2012 ; Vol. 7, No. 9.
@article{eab1a5746b744e6f8a236e39ed1c05f4,
title = "Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy",
abstract = "Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients",
author = "Itaru Anraku and Reena Rajasuriar and Dobbin, {Caroline A} and Richard Brown and Lewin, {Sharon R} and Andreas Suhrbier",
year = "2012",
doi = "10.1371/journal.pone.0045291",
language = "English",
volume = "7",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy. / Anraku, Itaru; Rajasuriar, Reena; Dobbin, Caroline A; Brown, Richard; Lewin, Sharon R; Suhrbier, Andreas.

In: PLoS ONE, Vol. 7, No. 9, e45291, 2012.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy

AU - Anraku, Itaru

AU - Rajasuriar, Reena

AU - Dobbin, Caroline A

AU - Brown, Richard

AU - Lewin, Sharon R

AU - Suhrbier, Andreas

PY - 2012

Y1 - 2012

N2 - Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients

AB - Circulating heat shock protein 60 (Hsp60) and heat shock protein 10 (Hsp10) have been associated with pro- and anti-inflammatory activity, respectively. To determine whether these heat shock proteins might be associated with the immune activation seen in HIV-infected patients, the plasma levels of Hsp60 and Hsp10 were determined in a cohort of 20 HIV-infected patients before and after effective combination anti-retroviral therapy (cART). We show for the first time that circulating Hsp60 levels are elevated in HIV-infected patients, with levels significantly reduced after cART, but still higher than those in HIV-negative individuals. Hsp60 levels correlated significantly with viral load, CD4 counts, and circulating soluble CD14 and lipopolysaccharide levels. No differences or correlations were seen for Hsp10 levels. Elevated circulating Hsp60 may contribute to the immune dysfunction and non-AIDS clinical events seen in HIV-infected patients

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460931/pdf/pone.0045291.pdf

U2 - 10.1371/journal.pone.0045291

DO - 10.1371/journal.pone.0045291

M3 - Article

VL - 7

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 9

M1 - e45291

ER -