@article{d3107f8b6e6242708deaf4d91fe86562,
title = "Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals",
abstract = "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defense against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27negCD45RA+CX3CR1+ Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB+ Vδ2+ T cells were observed in acute COVID-19 patients. SARS-CoV-2 infection did not alter the γδ T cell receptor repertoire of either Vδ1+ or Vδ2+ subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID-19 in unvaccinated individuals.",
keywords = "COVID-19, SARS-CoV-2, Vδ1 T cells, Vδ2 T cells, γδ T cells",
author = "{von Borstel}, Anouk and Nguyen, {Thi H.O.} and Rowntree, {Louise C.} and Ashhurst, {Thomas M.} and Allen, {Lilith F.} and Howson, {Lauren J.} and Holmes, {Natasha E.} and Smibert, {Olivia C.} and Trubiano, {Jason A.} and Gordon, {Claire L.} and Cheng, {Allen C.} and Kent, {Stephen J.} and Jamie Rossjohn and Katherine Kedzierska and Davey, {Martin S.}",
note = "Funding Information: This work was supported by an Australian Research Council (ARC) Discovery Early Career Researcher Award (DE200100292), a Rebecca L. Cooper Medical Research Foundation Project Grant (PG2020668), a Royal Society Wolfson Fellowship (RSWF/R2/222002) and an ARC Discovery Project (DP210103327) to MSD. National Health and Medical Research Council of Australia (NHMRC) Leadership Investigator Grant to KK (1173871) and JR (2008981); NHMRC Emerging Leadership Investigator Grant to THON (1194036) and LJH (2007884); a Jack Brockhoff Foundation Early Career Research Grant to LJH (JBF 4847‐2021); Research Grants Council of the Hong Kong Special Administrative Region, China to KK (T11‐712/19‐N); the Victorian Government to SJK; MRFF award to SJK (2002073), KK (1202445), KK, ACC, and SJK (2005544), and KK, JR, THON, LR, and SJK (2016062); NHMRC program grant to SJK (1149990) and NIH contract CIVC‐HRP to KK (HHS‐NIH‐NIAID‐BAA2018). Publisher Copyright: {\textcopyright} 2023 The Authors. Immunology & Cell Biology published by John Wiley & Sons Australia, Ltd on behalf of the Australian and New Zealand Society for Immunology, Inc.",
year = "2023",
month = apr,
doi = "10.1111/imcb.12623",
language = "English",
volume = "101",
pages = "321--332",
journal = "Immunology and Cell Biology",
issn = "0818-9641",
publisher = "John Wiley & Sons",
number = "4",
}