Circulating cellular immune response to oral immunization of humans with cholera toxin B-subunit

David J.M. Lewis; Luiz R.R. Castello-Branco; Pavel Novotny; Gordon Dougan; Terence A. Poulton; George E. Griffin

doi:10.1016/0264-410X(93)90005-I

Circulating cellular immune response to oral immunization of humans with cholera toxin B-subunit

David J.M. Lewis, Luiz R.R. Castello-Branco, Pavel Novotny, Gordon Dougan, Terence A. Poulton, George E. Griffin

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Peripheral blood mononuclear cells were taken from subjects before and after oral immunization with cholera toxin B-subunit. Cells obtained from naive volunteers before immunization did not proliferate in vitro to B-subunit. Oral immunization induced a proliferative response in all volunteers with a peak stimulation index of 20, and was detected up to 1 year later. The proliferative response kinetics suggest the appearance in the blood of primed T cells from the gut coinciding with the disappearance of primed plasmablasts from the circulation, supporting the concept of a common mucosal immune system in man for T and B cells.

Original language	English
Pages (from-to)	119-121
Number of pages	3
Journal	Vaccine
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/0264-410X(93)90005-I
Publication status	Published - 1 Jan 1993
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cholera toxin
immune response
mucosa
oral
T lymphocyte

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10.1016/0264-410X(93)90005-I

Cite this

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title = "Circulating cellular immune response to oral immunization of humans with cholera toxin B-subunit",

abstract = "Peripheral blood mononuclear cells were taken from subjects before and after oral immunization with cholera toxin B-subunit. Cells obtained from naive volunteers before immunization did not proliferate in vitro to B-subunit. Oral immunization induced a proliferative response in all volunteers with a peak stimulation index of 20, and was detected up to 1 year later. The proliferative response kinetics suggest the appearance in the blood of primed T cells from the gut coinciding with the disappearance of primed plasmablasts from the circulation, supporting the concept of a common mucosal immune system in man for T and B cells.",

keywords = "Cholera toxin, immune response, mucosa, oral, T lymphocyte",

author = "Lewis, \{David J.M.\} and Castello-Branco, \{Luiz R.R.\} and Pavel Novotny and Gordon Dougan and Poulton, \{Terence A.\} and Griffin, \{George E.\}",

year = "1993",

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doi = "10.1016/0264-410X(93)90005-I",

language = "English",

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pages = "119--121",

journal = "Vaccine",

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T1 - Circulating cellular immune response to oral immunization of humans with cholera toxin B-subunit

AU - Lewis, David J.M.

AU - Castello-Branco, Luiz R.R.

AU - Novotny, Pavel

AU - Dougan, Gordon

AU - Poulton, Terence A.

AU - Griffin, George E.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Peripheral blood mononuclear cells were taken from subjects before and after oral immunization with cholera toxin B-subunit. Cells obtained from naive volunteers before immunization did not proliferate in vitro to B-subunit. Oral immunization induced a proliferative response in all volunteers with a peak stimulation index of 20, and was detected up to 1 year later. The proliferative response kinetics suggest the appearance in the blood of primed T cells from the gut coinciding with the disappearance of primed plasmablasts from the circulation, supporting the concept of a common mucosal immune system in man for T and B cells.

AB - Peripheral blood mononuclear cells were taken from subjects before and after oral immunization with cholera toxin B-subunit. Cells obtained from naive volunteers before immunization did not proliferate in vitro to B-subunit. Oral immunization induced a proliferative response in all volunteers with a peak stimulation index of 20, and was detected up to 1 year later. The proliferative response kinetics suggest the appearance in the blood of primed T cells from the gut coinciding with the disappearance of primed plasmablasts from the circulation, supporting the concept of a common mucosal immune system in man for T and B cells.

KW - Cholera toxin

KW - immune response

KW - mucosa

KW - oral

KW - T lymphocyte

UR - https://www.scopus.com/pages/publications/0027398607

U2 - 10.1016/0264-410X(93)90005-I

DO - 10.1016/0264-410X(93)90005-I

M3 - Article

C2 - 8438610

AN - SCOPUS:0027398607

SN - 0264-410X

VL - 11

SP - 119

EP - 121

JO - Vaccine

JF - Vaccine

IS - 2

ER -

Circulating cellular immune response to oral immunization of humans with cholera toxin B-subunit

Abstract

UN SDGs

Keywords

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