Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis

Xingzhong Jin, Julieta Ruiz Beguerie, Weiya Zhang, Leigh Blizzard, Petr Otahal, Graeme Jones, Changhai Ding

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Abstract

Background: There is emerging evidence that the development and progression of osteoarthritis (OA) is associated with inflammation. C reactive protein (CRP), a systemic marker for inflammation, may be elevated in OA patients but the evidence is conflicting. Objective: To systematically review the literature for the relationship between serum CRP levels measured by a high sensitivity method (high sensitive CRP (hs-CRP)) and OA, as well as the correlation between circulating CRP levels and OA phenotypes. Methods: MEDLINE, EMBASE and CINAHL databases were systematically searched from January 1992 to December 2012. Studies were included when they met the inclusion criteria and data from studies were extracted. Two independent reviewers assessed study quality using a modified Newcastle-Ottawa Quality Assessment Scale. Meta-analyses were performed to pool available data from included studies. Results: 32 studies met the inclusion criteria. Serum hs-CRP levels in OA were modestly but statistically significantly higher than controls (mean difference=1.19 mg/L, 95 CI 0.64 to 1.73, p
Original languageEnglish
Pages (from-to)703 - 710
Number of pages8
JournalAnnals of the Rheumatic Diseases
Volume74
Issue number4
DOIs
Publication statusPublished - 2015

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