Circadian phenotype impacts the brain’s resting-state functional connectivity, attentional performance, and sleepiness

Elise R. Facer-Childs, Brunno M. Campos, Benita Middleton, Debra J. Skene, Andrew P. Bagshaw

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Introduction
Functional connectivity (FC) of the human brain’s intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC.

Study Objectives
The aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day.

Methods
Thirty-eight healthy individuals (14 male, 22.7 ± 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data.

Results
Fundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness.

Conclusion
Differences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotype.
Original languageEnglish
Article numberzsz033
Number of pages12
JournalSleep
DOIs
Publication statusAccepted/In press - 15 Feb 2019

Keywords

  • resting-state functional magnetic resonance imaging (fMRI)
  • circadian phenotype
  • sleep
  • default mode network
  • attentional performance
  • sleepiness
  • circadian rhythms

Cite this

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title = "Circadian phenotype impacts the brain’s resting-state functional connectivity, attentional performance, and sleepiness",
abstract = "IntroductionFunctional connectivity (FC) of the human brain’s intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC.Study ObjectivesThe aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day.MethodsThirty-eight healthy individuals (14 male, 22.7 ± 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data.ResultsFundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness.ConclusionDifferences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotype.",
keywords = "resting-state functional magnetic resonance imaging (fMRI), circadian phenotype, sleep, default mode network, attentional performance, sleepiness, circadian rhythms",
author = "Facer-Childs, {Elise R.} and Campos, {Brunno M.} and Benita Middleton and Skene, {Debra J.} and Bagshaw, {Andrew P.}",
year = "2019",
month = "2",
day = "15",
doi = "10.1093/sleep/zsz033",
language = "English",
journal = "Sleep",
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Circadian phenotype impacts the brain’s resting-state functional connectivity, attentional performance, and sleepiness. / Facer-Childs, Elise R.; Campos, Brunno M.; Middleton, Benita; Skene, Debra J.; Bagshaw, Andrew P.

In: Sleep, 15.02.2019.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Circadian phenotype impacts the brain’s resting-state functional connectivity, attentional performance, and sleepiness

AU - Facer-Childs, Elise R.

AU - Campos, Brunno M.

AU - Middleton, Benita

AU - Skene, Debra J.

AU - Bagshaw, Andrew P.

PY - 2019/2/15

Y1 - 2019/2/15

N2 - IntroductionFunctional connectivity (FC) of the human brain’s intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC.Study ObjectivesThe aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day.MethodsThirty-eight healthy individuals (14 male, 22.7 ± 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data.ResultsFundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness.ConclusionDifferences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotype.

AB - IntroductionFunctional connectivity (FC) of the human brain’s intrinsically connected networks underpins cognitive functioning and disruptions of FC are associated with sleep and neurological disorders. However, there is limited research on the impact of circadian phenotype and time of day on FC.Study ObjectivesThe aim of this study was to investigate resting-state FC of the default mode network (DMN) in Early and Late circadian phenotypes over a socially constrained day.MethodsThirty-eight healthy individuals (14 male, 22.7 ± 4.2 years) categorized as Early (n = 16) or Late (n = 22) using the Munich ChronoType Questionnaire took part. Following a 2-week baseline of actigraphy coupled with saliva samples for melatonin and cortisol rhythms, participants underwent testing at 14:00 hours, 20:00 hours, and 08:00 hours the following morning. Testing consisted of resting-state functional magnetic resonance imaging (fMRI), a structural T1 scan, attentional cognitive performance tasks, and self-reported daytime sleepiness. Seed-based FC analysis from the medial prefrontal and posterior cingulate cortices of the DMN was performed, compared between groups and linked with behavioral data.ResultsFundamental differences in the DMN were observed between Early and Late circadian phenotypes. Resting-state FC of the DMN predicted individual differences in attention and subjective ratings of sleepiness.ConclusionDifferences in FC of the DMN may underlie the compromised attentional performance and increased sleepiness commonly associated with Late types when they conform to a societally constrained day that does not match their intrinsic circadian phenotype.

KW - resting-state functional magnetic resonance imaging (fMRI)

KW - circadian phenotype

KW - sleep

KW - default mode network

KW - attentional performance

KW - sleepiness

KW - circadian rhythms

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M3 - Article

JO - Sleep

JF - Sleep

SN - 0161-8105

M1 - zsz033

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