TY - JOUR
T1 - Cinnamate of inulin as a vehicle for delivery of colonic drugs
AU - López-Molina, Dorotea
AU - Chazarra, Soledad
AU - How, Chee Wun
AU - Pruidze, Nikolov
AU - Navarro-Perán, Enma
AU - García-Cánovas, Francisco
AU - García-Ruiz, Pedro Antonio
AU - Rojas-Melgarejo, Francisco
AU - Rodríguez-López, José Neptuno
N1 - Funding Information:
This work was supported by grants from Ministerio de Ciencia e Innovación (MICINN) (SAF2013-48375-C2-1-R), Fundación Séneca, Región de Murcia (FS-RM) (15230/PI/10), and EU ERA293514. S.C was contracted by this EU project. C.W.H. has a fellowship from the EC Erasmus Mundus Program.
Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - Colon diseases are difficult to treat because oral administrated drugs are absorbed at the stomach and intestine levels and they do not reach colon; in addition, intravenous administrated drugs are eliminated from the body before reaching colon. Inulin is a naturally occurring polysaccharide found in many plants. It consists of β 2-1 linked d-fructose molecules having a glucosyl unit at the reducing end. Various inulin and dextran hydrogels have been developed that serve as potential carrier for introduction of drugs into the colon. Because inulin is not absorbed in the stomach or in the small intestine, and inulin is degraded by colonic bacteria, drugs encapsulated in inulin-coated vesicles could be specifically liberated in the colon. Therefore, the use of inulin-coated vesicles could represent an advance for the treatment of colon diseases. Here, we study the use of a cinnamoylated derivative of chicory inulin as a vehicle for the controlled delivery of colonic drugs. The encapsulation of methotrexate in inulin vesicles and its release and activity was studied in colon cancer cells in cultures.
AB - Colon diseases are difficult to treat because oral administrated drugs are absorbed at the stomach and intestine levels and they do not reach colon; in addition, intravenous administrated drugs are eliminated from the body before reaching colon. Inulin is a naturally occurring polysaccharide found in many plants. It consists of β 2-1 linked d-fructose molecules having a glucosyl unit at the reducing end. Various inulin and dextran hydrogels have been developed that serve as potential carrier for introduction of drugs into the colon. Because inulin is not absorbed in the stomach or in the small intestine, and inulin is degraded by colonic bacteria, drugs encapsulated in inulin-coated vesicles could be specifically liberated in the colon. Therefore, the use of inulin-coated vesicles could represent an advance for the treatment of colon diseases. Here, we study the use of a cinnamoylated derivative of chicory inulin as a vehicle for the controlled delivery of colonic drugs. The encapsulation of methotrexate in inulin vesicles and its release and activity was studied in colon cancer cells in cultures.
KW - Cinnamoylated inulin
KW - Colon drug delivery
KW - Inulin
KW - Inulinase
KW - Methotrexate
UR - http://www.scopus.com/inward/record.url?scp=84920866413&partnerID=8YFLogxK
U2 - 10.1016/j.ijpharm.2014.12.064
DO - 10.1016/j.ijpharm.2014.12.064
M3 - Article
C2 - 25550210
AN - SCOPUS:84920866413
SN - 0378-5173
VL - 479
SP - 96
EP - 102
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1
ER -
