Cingulotomy in the rat fails to block opiate withdrawal effects but elevates stress-induced plasma beta-endorphin

Graeme C. Smith, Gregory L. Willis, Avid L. Copolow, Heribert Recher, Louis Roller

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)


1. 1. Male, albino, Sprague Dawley rats underwent surgical Cingulotomy or sham opperatiqn and were then implanted with subcutaneous morphine pellets or exposed to forced running. 2. 2. The conditions of Cingulotomy or forced running alone did not cause a significant increase in plasma i.r. Beta endorphin concentrations. 3. 3. The combined treatment of Cingulotomy plus forced running caused a significant elevation of plasma β-endorphin concentrations. 4. 4. The cingulum is involved in the elicitation of stress hormone responses in the rat.

Original languageEnglish
Pages (from-to)683-688
Number of pages6
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Issue number5
Publication statusPublished - 1 Jan 1988


  • Beta endorphin
  • cingulum bundle
  • forced running
  • morphine addiction
  • morphine withdrawal
  • stress

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