Chronic Inflammation and Innate Immunity in Alzheimer's Disease - Role of Diet

Louise E. Bennett, Julie Nigro, Michael Bird, Erika Gyengesi, Stuart Lance MacAulay, Gerald Münch

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Abstract

The immune system utilizes an army of cellular and molecular agents to protect against adverse effects of chronic diseases. The immune surveillance of the brain is mediated by cell types specific to the brain but responsive to the same effector species as the peripheral immune system, which can circulate across the blood-brain barrier and influence its inflammation status. In the presence of peripheral chronic disease, proinflammatory mediators produced in the periphery can mediate a proinflammatory response in the brain. This can explain why antiinflammatory therapies, including protective dietary patterns, taken in midlife, may be protective against development of Alzheimer's disease (AD) in later life. Regulation of peripheral inflammation may thus suppress proinflammatory immune signaling to the brain and delay neurodegeneration. However, in symptomatic mild cognitive impairment and AD, when the perpetual cycle of damage-associated molecular patterns (DAMPs) generate localized inflammation, stimulation and not suppression of the peripheral immune system may be theoretically required to promote phagocytosis of amyloid by macrophages, seeking to resolve the inflammation cycle. However, the AD brain also requires local immunesuppression to circumvent the DAMP cycle. Consumption of immunomodulatory dietary factors offers potential for regulation of chronic inflammation.

Original languageEnglish
Title of host publicationDiet and Nutrition in Dementia and Cognitive Decline
EditorsColin R. Martin, Victor R. Preedy
Place of PublicationLondon UK
PublisherElsevier
Chapter21
Pages223-233
Number of pages11
Edition1
ISBN (Electronic)9780124079397
ISBN (Print)9780124078246
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Alzheimer's disease risk
  • Antiinflammatory
  • Diet
  • Immune stimulation
  • Immune-modulation
  • Inflammation
  • Innate immune system
  • Intervention
  • Lifestyle
  • Prevention

Cite this